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DRUG CLASS AND MECHANISM : It has been established that 140 million men worldwide suffered from impotence affects and half from them are thought to have some physical (medical) cause which include diabetes and circulatory, neurological or urological conditions. Oters are believed to have psychogenic causes of impotence. The engorgement of the penis with blood leads to penile erection. This engorgement appears in case of delivering blood to the penis by the blood vessels which results to extending in size and increasement the delivery of blood to the penis. Under normal conditions, sexual stimulation provoke the production and release of nitric oxide in the penis. Nitric oxide then activates the enzyme, guanylate cyclase, which causes the production of cyclic guanosine monophosphate (cGMP). This enzyme is necessary for the erection by affecting the quantity of blood that the blood vessels deliver and remove from the penis. Sildenafil (Viagra) also decreases the pressure in the pulmonary artery in a serious condition called pulmonary arterial hypertension. By blocking an enzyme called phosphodiesterase-5 (PDE5) which destroys the cGMP sildenafil (Viagra) averts the destruction of cGMP and allows cGMP to accumulate and persist longer. This situation leads to more prolonged engorgement of the penis.
