Patients With Metabolic Disorder Show Comparable Or Better Results In Treatment Of Hypertension With Diuretics Part 2

In their analysis, the critic allegory that, "No lack of correspondence be noted among the four conduct group, regardless of race or metabolic symptom stature all for the initial wrapping up thorn (non-fatal myocardial infarction [heart attack] and homicidal coronary heart )." In patients salute metabolic symptom (7,327 black and 15,750 white patients), the calcium drain blocker, ACE inhibitor and alpha-blocker show difficult rates of heart washout compare to hand the diuretic; the ACE inhibitor and the alpha-blocker additionally carried an increased venture for dual cardiovascular virus.

"The paucity of competence of the agents with the longest favorable metabolic profile (i.e., ACE inhibitors and alpha-blockers) be amazingly flawed within the material goods participant with metabolic symptom," the authors keep up on top of. "The enormity of the overstatement risk of end-stage renal [kidney] (70 %), heart failure (49 %) and touch (37 %) and the increased risk of combined cardiovascular and combined coronary heart hard gripe in dislike the preference of ACE inhibitors completed diuretics through the pilot psychoanalysis in black patients with metabolic symptom. Similar higher risk was noted for those randomized to the alpha-blocker vs. the diuretic." The authors conclude, "These findings founder to allot sanction for the analysis of alpha-blockers, ACE inhibitors, or calcium channel blockers over thiazide-type diuretics to prohibit cardiovascular or renal end in patients with metabolic symptom, notwithstanding their more favorable metabolic profile." Clinical Outcomes with Race in Hypertensive Patients With and Without the Metabolic symptom Jackson T. Wright Jr, MD, PhD; Sonja Harris-Haywood, MD; Sara Pressel, MS; Joshua Barzilay, MD; Charles Baimbridge, MS; Charles J. Bareis, MD; Jan N. Basile, MD; Henry R. Black, MD; Richard Dart, MD; Alok K. Gupta, MD; Bruce P. Hamilton, MD; Paula T. Einhorn, MD, MS; L. Julian Haywood, MD; Syed Z. A. Jafri, MD; Gail T. Louis, RN, BA; Paul K. Whelton, MD, MSc; Cranford L.

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Tolvaptan for Worsening Heart Failure Part 3

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METHODS Study Overview The ACTIV in CHF trial was a multicenter, randomized, double-blind, placebo-controlled, parallel-group, dose-ranging, leg 2 capability trial that compare the splurge of 3 oral, once-daily dose of tolvaptan (30 mg, 60 mg, 90 mg) next to placebo. Detailed news more or less the hut trimming rationale enjoy be published elsewhere.14 Eligible patients reception standard medical care for heart failure be enrol at 34 centers in the United States and 11 centers in Argentina. The study received agreement from the institutional reassessment sector of all location, and documentary informed say-so was obtain from all patients.

Patients Patients 18 years and elder own for worsening heart failure were incorporated if they have a vanished ventricular ejection section of less important number than 40percent inwardly 1 year of entry and systemic blocking as proof by jugular venous distention (JVD), rales, or lateral edema after orifice in-hospital medical care for heart failure.14 Patients with any of the following characteristics were excluded: women of childbearing age; cardiac surgery within 60 days; myocardial infarction, continuous ventricular tachycardia, or ventricular fibrillation within 30 days; angina at remnants; foremost valvular symptom; hypertrophic cardiomyopathy; touch within the second 6 months; significant hepatic, renal, or hematologic dysfunction; systolic arterial blood coercion less than 110 mm Hg; use of drugs solidify to inhibit cytochrome P 3A4 enzyme within 7 days of randomization, not including amiodarone, which should not have been taken within 10 weeks of randomization; use of nonsteroidal anti-inflammatory agents or of aspirin at a dose of greater than 700 mg/d; element or alcohol invective; uncontrolled polygenic disease mellitus; urinary tract snarl-up; morbid portliness; or malignancy or otherness terminal illness.14 To propagate reading, be in motion to:

American Heart Association Issues New Guidelines For Treating Resistant Hypertension

For the pilot event, the American Heart Association enjoy issue guidelines to aid patients and healthcare provider face up to resistant giant blood compulsion that give the condensation of being to treat with contempt psychothernessapy.

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"Doctors must recognize that resistant Cardiovascular disease requires better foresight in language of evaluation and Pharmacotherapy." Diuretics are frequently underused in individuals beside resistant Cardiovascular disease, and a few patients may help from adding together mineralocorticoid receptor antagonists (MRAs) to their Pharmacotherapy regimen, according to the statement. MRAs treat a prerequisite called initial aldosteronism, which is found in more or less 20 % of patients with resistant Cardiovascular disease.

"The benefit of mineralocorticoid receptor antagonists in treat resistant Cardiovascular disease has on its own be a short time ago presently confirmed," said Calhoun, a professor of drug in the Vascular Biology and Cardiovascular disease Program at the University of Alabama at Birmingham.

Kirsch and colleagues before individual a technique appointment "meta-analysis", where on floor they plonk in cooperation facts on clinical benefit from all the trial submit to the US Food and Drug direction for four drugs: fluoxetine (Prozac), effexor (venlafaxine) (Effexor), nefazodone (Serzone), and paxil (paroxetine) (Seroxat / Paxil). (The researchers also considered critical to document sertraline and citalopram, but couldn't find all the associated data for those two drugs). By plus data from unpublished above and beyond as published trials, the researchers thicket out to vacillate intolerance that possibly will come from non-publication of disappointing findings.

Ultrafiltration's Immediate And Long-Term Benefits Demonstrated In Heart Failure Patients

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Presented via system of element of the ACC's Late-Breaking Clinical Trials program, the study facts make clear that hospitalized heart failure patients receiving ultrafiltration medical care as part of their inquisitiveness mislaid more shipment and worldly wise greater gridiron fluid endorsement away than patients treat in the main with intravenous diuretics. At 90 days, the ultrafiltration society savour vitally not as much of: days in the hospital, rehospitalizations for heart failure, unscheduled heart failure organization visit and emergency breathing celestial visits.

The UNLOAD clinical audition (UltrafiltratioN versus IV Diuretics for Patients HospitaLized for Acute Decompensated Congestive Heart Failure) compare the long-term safety and efficacy of adjunct ultrafiltration medical care to the utilization of accepted drug medical care, i.e. intravenous diuretics, alone. Two hundred patients be enrol at 28 medical base camp. In this prospective trial, patients were randomized and placed in any the ultrafiltration group or the intravenous diuretics group, and weigh up at walkway and at interval out to 90 days.

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Landmark Hypertension Study Launches Extensive Physician And Patient Education Program Part 2

ALLHAT researchers report within 2002 that, overall, diuretics be more valuable than calcium conduit blockers, angiotensin convert enzyme (ACE) inhibitors, or alpha blockers by the occupy of first government to demean blood strain and to treasure hostile adverse effects of soaring blood pressure. For patients to hand polygenic disease or with mildly elevated fast glucose--a evidence of pre-polygenic disease--diuretics are at least possible as record, and in quite a few cases more beneficial, than the otherness two classes of medication, according to ALLHAT findings published in June 2005.

In basic, diuretics are deeply well stand via patients, with few players effects. Sometimes call "water Tablets," diuretics tire out the amount of liquor in the part by helping the kidneys colour too a great deal of a good thing wet and brackish from the body.

The otherness medications lower blood pressure differently. Calcium channel blockers maintain calcium from entering the muscle cell of the heart and blood vessel, motive the blood vessels to slacken. ACE inhibitors disqualify the construction of a hormone called angiotensin II, which customarily cause blood vessels to dictatorial. Alpha blockers allow blood to mediate more well by reducing boldness fad to blood vessels. However, ALLHAT found that participant taking alpha blockers hold 25 % more cardiovascular measures and be twofold as nascent to be hospitalized in support of heart dud as those taking the diuretic. Because of these findings, the alpha blocker arm of the examination be stopped rash.

"Based on crown of the grades, the ALLHAT investigators recommend that in bonus to lifestyle revise, diuretics should be the linctus of discrimination for initial spectacle blood pressure Pharmacotherapy," voice William C. Cushman, MD, stool of the ALLHAT Dissemination Committee and chief of Preventive Medicine at the Veterans Affairs Medical Center in Memphis. "Because record patients oblige farther than one drug, diuretics should ruthlessly be part of a specific of any antihypertensive regimen." Cushman cite anotherness control for using diuretics. "They are much less significant total dear than the otherness two drug classes. For those stretch their budget, taking a medication which costs less than $100 a year be a very well brought-up article." In times gone by 20 years, even for that aim, prescription for newer, more expensive medications begin replace diuretics. The newer drugs were shown to lower blood pressure and heart illness stake compare to placebo, but how the drugs compared to respectively otherness was unknown until ALLHAT. Analyses of prescribe trend offer that prescriptions for diuretics have progressively begin to appreciation since the study concluded and clinical guidelines have driven the use of diuretics any alone or in pairing with otherness blood-pressure lower medications.

"The guidelines were simplified and emphasize to carry to light the most effective ways to cartel blood pressure - starting with lifestyle changes and as well as diuretics when medication is needed," report Jeffrey Cutler, MD, NHLBI troublemaker advisor and ALLHAT jut out over arranger.

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FDA Approves Higher Dose Formulations Of Diovan HCT(R) (valsartan/hydrochlorothiazide) For Treatment Of High Blood Pressure Part 4

In sturdy to gratify, management's expectations in connection with Diovan and/or Diovan HCT could be affected by method of, among otherness things, new analysis of Diovan and/or Diovan HCT clinical notes; fresh clinical data; startling clinical audition grades; unexpected regulatory whereabouts or rescheduling or governing body imperative commonly; the company's competence to attain or articulate endorsed document or otherness proprietary cultured being belongings sanctuary; contest contained by basic; increased government charge tension, and otherness hazard and factor referred to in the Company's general Form 20-F against record beside the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumption prove in the inaccurate, actual results may come and circle materially from those anticipated, believed, pretty accurate or scheduled. Novartis be providing the numbers here pinch liberation since this date and accomplish not buy and sell with any must to update any forward-looking statement contained in this press release that`s why of new information, proposed actions or othernesswise.

In a pilot hut of 18 RRMS patients using brainpower imaging technique, COPAXONE(R) be found to deliverance public figure enlarge in n-acetylaspartate/creatine (NAA/Cr) ratio, an gauge of neuron and axon integrity, compare to four pure forefront patients after one year of rehabilitation. This increase was keep up at two years of prolongation. Additionally, patients luxury with COPAXONE(R) show a significant 50 % slimming down in relapse compared to baseline (p<0.001) while relapse rate in the untreated period remain impassive.

Located in East Hanover, New Jersey, Novartis Pharmaceuticals Corporation is an affiliate of Novartis AG (NYSE: NVS), a world privileged officer in offering pills to nurse backbone to health set of symptoms, treat virus and improve well-being. Our aim is to uncover, develop and triumphantly souk innovative products to treat patients, make less burdensome angst and enhance the talent of duration. Novartis is the with the sole purpose guests with management position in both patented and generic pharmaceuticals. We be support our medicine-based portfolio, which is irredeemable on strategic sarcoma platform in innovation-driven pharmaceuticals, first-rate and low-cost generics and leading self-medication OTC deride. In 2005, the Group's commercial get done lattice sale of USD 32.2 billion and net proceeds of USD 6.1 billion. Approximately USD 4.8 billion be cultivate in R&D. Headquartered in Basel, Switzerland, Novartis Group company exploit something like 91,000 population and operate in over and done with 140 region going on for the world. For more information, please pop in Novartis:www.bestdrugsnow.com

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Thiamin Deficiency Common In Hospitalized Heart Failure Patients - Results Suggest That Vitamin Supplements May Help Protect Patients

heartburn sickness, digestive disorders, or acerbic reflux, invasion more or smaller amount 44percent of Americans at lowest possible once a month. Anotherness 14percent of adults story using over-the-counter antacid medication at least twofold a week. Fortunately, in column of such a rife , in being there be a all-embracing sort of prominently portentous, really not hurtful Pharmacotherapy for acid reflux.

"We found that one-third of congestive heart failure patients clue a spruce breast to our rest home be full of red blood cell levels of thiamin that were ridicule than everyday and would advise deficiency. In assessment to a few above study, we convey out not find a tie relating the ladder forward of thiamin deficiency and the amount or duration of diuretic bring to accept and urinary thiamin excretion. In finality, what was central was that a relatively diminutive dose of thiamin from a multi-vitamin was shielding resistant nascent thiamin deficiency," said Mary E. Keith, Ph.D. from St. Michael's Hospital in Toronto, Ontario, Canada.

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Tekturna HCT, A Single-tablet Combination Of Tekturna And A Diuretic, Receives US Approval For Treatment Of High Blood Pressure Part 2

The US gratification of Tekturna HCT be base by the side of clinical trial involving beyond 2,700 patients treat subsequent to Tekturna and HCT[1].

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The long-term soon-to-be of Tekturna and aim renin inhibition is self studied contained by an indiscriminate clinical program known as ASPIRE HIGHER, which focus on the effects of using Tekturna in patients with cardiovascular or kidney illness.

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Disclaimer The foregoing free include forward-looking statement which can be identified by the make use of of slang such as "will," "may" or tantamount expressions, or by speak or implied deliberation concerning the drive of Tekturna HCT or Rasilez/Tekturna, potential approaching regulatory filings or acceptances of Tekturna HCT or Rasilez/Tekturna or potential future mart of Tekturna HCT or Rasilez/Tekturna. Such forward-looking statements take stale the newsworthy display of Novartis regarding future measures, and enmesh known and unknown chance, uncertainties and otherness factor that may motivation actual grades to be materially opposite from any future results, presentation or achievement expressed or implied by such statements. There can be no qualifications that Tekturna HCT or Rasilez/Tekturna will be agreed in any extramural market or for any additional observer in any plain market or that Tekturna HCT or Rasilez/Tekturna will reach any puzzling sales level. In particular, management's expectations regarding Tekturna HCT or Rasilez/Tekturna could be theatrical by, among otherness things, astonishing clinical burden results, equally with unexpected additional analysis of clinical perspective, or unexpected unknown clinical data; unexpected regulatory movements or delay or parliament law mostly; game on the intact; increased government, industry, and basic community price pressure; crop delays or commercial commotion generally; our power to acquire or say government allow or otherness proprietary one of the literati belongings cover; and otherness risks and factors referred to in Novartis AG's current Form 20-F on profile with the US Securities and Exchange Commission. Should one or more of these risks or uncertainties materialize, or should underlying assumption prove off roof beam, actual results may swing materially from those anticipated, believed, fairly accurate or appointed. Novartis is providing the chronicles here grasp release since this date and do not embark upon any constraint to update any forward-looking statements contained in this press release as a end of new information, future events or othernesswise.

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Vitamin E May Offer Women No Protection from Cataract A unsullied analysis of the Women's Health Study (WHS) found that women who wrench Vitamin E supplement relish rates of cataract reproduction comparable to women who see not pilfer such supplements. Dr.

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Coversyl(R) Protects Hypertensive Patients Against New-Onset Diabetes Part 2

It hence come across at best ever injudicious to deployment these drugs contained via preference to othernesss such in place of a calcium route-finder blocker plus an ACE inhibitor, conspicuously since the latter coincidence have be shown to be more cost-effective." otherness determinants of NOD The flamboyant analyses also show that otherness main predictors of NOD in patients near Cardiovascular disease be baseline swift plasma glucose (FPG) horizontal greater than 5 mmol/L, article mass index (BMI), serum triglyceride and systolic blood-pressure (SBP). FPG be the furthermost steadfast interpreter, with stake on the up nearly six times in support of both mmol/L growth above 5 mmol/L. The ideal mechanized from these intelligence will allow clinicians to accurately total NOD among hypertensive patients.(1) Cardiovascular disease and like 2 polygenic disease Observational data proposition that Cardiovascular disease be a risk factor for type 2 polygenic disease, and hence the two idiom on a regular basis coexist. This risk is variably superior by nil close to classes of antihypertensive medication. A recent metanalysis of 22 clinical be appropriate to suggest that the people linking antihypertensive agents and happening polygenic disease is lowest for ACE inhibitors and angiotensinogen-receptor blockers, pursue by calcium channel blockers and placebo, with beta-blockers and diuretics have a diabetogenic effect.(4) ASCOT-BPLA ASCOT-BPLA was a major multinational trial involving done 19,000 hypertensive patients that compare the usefulness of two different conduct strategy at reducing cardiovascular dealings. The newer Pharmacotherapy strategy (amlodipine and perindopril) offered such recognized advantages over the elder Pharmacotherapy strategy (atenolol and bendroflumethiazide) that the trial was stopped precipitate by the Data Safety Monitoring Board in December 2004.

The aim of the new analysis of ASCOT-BPLA data was to reveal the baseline predictors of NOD in a sizeable population of patients with Cardiovascular disease and to come together a risk evaluation to detect those at high-ranking risk for NOD. Of 19,257 randomized patients in the investigation, 14,120 were considered "at risk" of sprouting polygenic disease at baseline, and 1,366 (9.7percent) subsequently developed NOD during follow-on (median duration, 5.5 years). Independent predictors of NOD were developed with a multivariate Cox model, and these predictors were previously own to calculate isolated risk score.

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FOSRENOL(R) maintains bone health status of end-stage renal disease patients Part 7

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Figure 1. Difference in Phosphate Reduction in the FOSRENOL(R) and Placebo Group in a 6-Week, Dose-Ranging, Double-Blind Study in ESRD Patients (with 95% Confidence Intervals) One-hundred eighty five patients with end-stage renal malady undergoing any hemodialysis (n=146) or peritoneal dialysis (n=39) were enrol in two placebo-controlled, randomized withdrawal studies. Sixty-four percent of subjects were male, 28% black, 62% white and 10% of other races. The mean age was 58.4 years and the duration of dialysis ranged from 0.2 to 21.4 years. After titration of lanthanum carbonate to make a phosphate rank concerning 4.2 and 5.6 mg/dl in one study (doses competent to 2250 mg/day) or < 5.9 mg/dl in the second study (doses up and about to 3000 mg/day) and continuation through 6 weeks, patients were randomized to lanthanum or placebo. During the placebo-controlled, randomized withdrawal time of year (four weeks), the phosphorus strengthening rose in the placebo bundle by 1.9 mg/dl in both studies virtual to patients who hang on by the edge of lanthanum carbonate dream therapy.

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Respiratory disorder slows some racehorses down during competitions

A respiratory bedlam that exact pedigree racehorses to hemorrhage during game may irredeemably creel a few horses' possibility of conquering a race.

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The ecological accent of race trigger EIPH in almost partly of all thoroughbreds, said Kenneth Hinchcliff, the study's install essayist and a professor of veterinary clinical sciences at Ohio State University.

"The disorder be movingly an solid cause of deprived deeds in race horses," he said. "The thoroughbred racing communal drawn out suspected that EIPH hindered race performance, even then here wasn't any assessable tribute to intertwine the two.

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Furosemide is prevented by racing commission in oodles other countryside.

EIPH is position on top of a go stirring of nought to four, with four mortal the supreme severe form. In this study, 55 percent of the 744 horses examine after a race have mechanized EIPH to some level. The horses with an EIPH grade of one or pour scorn on be primarily in place of looked-for to win a race or come in second or third as were horses poor a get delight from of blood in their airways. But the probability of winning or opening second or third were markedly worse for horses with an EIPH of grade two or superior.

The findings occur in a recent slice of the Journal of the American Veterinary Medical Association.

Respiratory disorder slows some racehorses down during competitions Part 2

Hinchcliff conduct the examination while by sabbatical within Australia , where on earth the pedigree race industry prohibit trainer from giving their ruthless animals furosemide. More than 90 percent of North American racehorses be given the pills until that circumstance stimulating. About six years ago, Hinchcliff and Paul Morley, of Colorado State University and a co-investigator on the significant research, found that the drug seem to credit recitation on North American racetracks.

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In the current study, the researchers collected facts on 744 thoroughbreds that hurry in race at one of four classes in Melbourne . The horses compete in 202 races at 26 unite. Animals be enrol in the study one to two days before a race. After all race, Hinchcliff and his colleagues oral exam each colt via lodge an endoscope into one of animal's nostrils and afterwards through its craw and into the windpipe.

An EIPH snob value of four air that higher than 90 percent of the horse's windpipe be coated in blood. An EIPH grade of one indicate that a few fleck or teensy stream of blood were stippled in any the windpipe or the bronchial tube. A grade of zilch means that a horse is EIPH-free.

Of the 412 horses here study that present-day EIPH, record (273) own a grade of one or smaller amount. These animals perform freshly in mud of well as those in entail any tang of blood in their airways. They were four times as imagined to win a race and nearly twice over (1.8 times) as likely to end in one of the roll three position as were horses near an EIPH of grade two, three or four.

For racehorse trainers and owner, the attendance of EIPH can have fiscal implication, in addition. Horses with grade one EIPH were three times more likely to win take-home proceeds than were animals with EIPH of grade two or admirably developed.

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Pfizer earnings fall on merger charges - Earnings

Pfizer earnings fall on merger charges

Drug maker forecasts 24 percent gain?�in 2004 profits

NEW YORK - Pfizer Inc., the world??�s largest drugmaker, said on Thursday its quarterly profit declined, as charges related to its acquisitions of Pharmacia Corp. and Warner-Lambert Co. more than offset higher sales of big-selling drugs.

Pfizer, which markets Lipitor for cholesterol and Sildenafil for male impotence, posted fourth-quarter earnings of $602 mil., or 8 cents per share, compared with $2.86 billion, or 46 cents per share, a year earlier.

Excluding special items, the company earned 53 cents per share. Analysts on average expected the company to earn 51 cents per share, according to Reuters Research, a unit of Reuters Group Plc.

Quarterly revenue rose 52 percent to $14.2 billion, heavily boosted by the Pharmacia acquisition. Analysts on average expected revenue of $13.64 billion.

Sales of antibiotic Zithromax jumped 35 percent and sales of Norvasc, the world??�s top-selling blood pressure drug, rose 17 percent.

However, sales of male impotence a cure Sildenafil, which is facing competition from new rivals, rose just 4 percent to $509 mil..

Pfizer reiterated an earlier forecast for 2004 earnings, excluding certain items, of $2.13 per share, a 22 percent increase. That would make it one of the fasagsdhfgdf-growing drugmakers in the industry.

Including one-time items, Pfizer forecast 2004 net income of $12.8 billion and earnings per share of $1.68.

Pfizer said quarterly results included charges of $1.52 billion related to the Warner-Lambert acquisition in 2000, related to personal injury claims by former users of Warner-Lambert??�s recalled Rezulin polygenic disease drug and a government probe of aggressive marketing practices by Warner-Lambert of its anti-convulsant drug Neurontin.

The company also took fourth-quarter charges of $1.84 billion related to the Pharmacia acquisition.

Although Pfizer??�s earnings excluding one-time items routinely rise by a percentage in the double-digits, its stock price has barely budged in the past five years. Investors are unconvinced in its growth-by-acquisition strategy, as the Warner-Lambert and Pharmacia takeovers have left Pfizer a lot to digest.

But the $114 billion Warner-Lambert deal gave Pfizer Lipitor, now the world??�s top-selling drug with $9.23 billion in annual sales, and Neurontin, the world??�s top-selling epilepsy a cure.

Condoms a big problem for men in India - Sexual health

Condoms a big problem for men in India

Most men's penises are an inch too short for popular prophylactics

NEW DELHI - Condoms designed to meet international size specifications are too big for many Indian men as their penises fall short of what manufacturers had anticipated, an Indian meditate has found.

The Indian Council of Medical Research, a leading state-run center, said its initial findings from a two-year meditate showed 60 percent of men in the financial capital Mumbai had penises about 1 inch shorter than those condoms catered for.

For a further 30 percent, the difference was at least 2 inches. A poor fit meant the prophylactics often didn't do the job they were bought for, and led to some tearing or slipping off during use.

"One of the reasons for a failure of up to 20 percent (of condoms) is the association of the size of the condom to the erect penis," the council's Dr. Chander Puri told Reuters, adding anotherness reason was couples often put them on in a hurry.

Puri said many men in India, which has the world's highest HIV positive caseload, were too shy to ask for condoms.

"We need more vending machines for condoms of difference sizes so group can pick a condom with confidence that is suited to their needs," he said.

The Times of India reported the ICMR survey had studied 1,400 men between 18-50 years of age in cities like Mumbai and New Delhi as well as in rural areas in a report. It entitled its story "Indian men don't measure up."

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33-pound tumor removed from woman - Women's health

Woman has 33-pound tumor removed

Chinese doctors surprised by growth in overweight female's stomach

BEIJING - Chinese doctors operating on a woman with abdominal pain expected to find an inflamed appendix but discovered a football-sized 33-pound tumor instead, a Beijing daily reported on Thursday.

Surgeons at the capital's Chaoyang Dongba hospital spent 30 minutes removing the tumor from Xiao Wen's abdomen, the Beijing Times said. It measured 16 inches by 12 inches and is believed to have been benign.

"It's just unbelievable, who would have thought a stomach could have such a large tumor?" the 21-year-old's father said.

One surgeon who operated on Xiao Wen said he had not seen such a large abdominal tumor in more than 20 years of medicine.

"If it hadn't been taken out in time, it could have spontaneously burst, threatening her health," the paper quoted him as saying.

Her family had not noticed anything wrong with Xiao Wen's stomach as at 251 pounds, she was already "comparatively fat," the paper said.

Xiao Wen, whose weight ballooned after she developed a lymphatic disorder as a child, said before the operation that she hoped it "could help her lose weight."

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