Keryx Biopharmaceuticals Announces Completion Of Patient Randomization Into Sulonex Phase III Pivotal Study Part 4

Ranbaxy Laboratories Limited, headquartered in India, is an integrated, research based, large-scale pharmaceutical company produce a broad size of thorn, affordable generic medication, trusted with healthcare professionals and patients across geography. Ranbaxy's uninterrupted focus on R&D have resulted in several approvals in selling market and faddy progress in New Drug Discovery Research. The Company's foray into Novel Drug Delivery Systems has front to proprietary "platform technologies", follow-on in several products underneath intensification. The Company is portion its clientele in ended 125 bucolic and has an expanding international portfolio of affiliate, joint venture and alliances, dust operation in 49 countries and manufacturing operations in 11 countries.

ABOUT SULONEX(TM) Sulonex (sulodexide oral gelcap) belong to a proposed exotic communal order of nephroprotective, or kidney protecting, drugs, set as the glycosaminoglycans. A group of beneficiary of this chemical race wallow in be shown to cut rear on pathological albumin excretion in diabetic nephropathy in human. Some of the members of this chemical family consist of the subsequent accepted drugs: rule heparin, short molecular consignment heparin and danaparoid. These agents all dictate psychotherapy by immunisation and be all potent anticoagulants, which are blood thinners proficient of inducing bleeding. Sulonex, on the other foot, be given in words and, here kind, have demonstrated undersized, if any, anticoagulant effects to date.

Keryx particular the elite rights to disbursement Sulonex(TM) for the nurture of diabetic nephropathy in North America, Japan and incontrovertible other market exterior of Europe. Diabetic nephropathy is a long-term complication of diabetes where on earth the kidneys are increasingly worn. Sulonex is a glycosaminoglycan combined with structural similarity to the substantial family of market heparins and low molecular weight heparins. This pills has been marketed in a signs of European, Asian and South American province for abundant years by our licensor for certain cardiovascular requisites and has an matured sanctuary profile at the dose previously owned for such protest drum up. Additionally, it has been demonstrated in multiple clinical trials conducted in Europe and the U.S., plus two randomized, double-blind, placebo-controlled Phase II studies, that Sulonex can reduce urinary protein excretion in patients with diabetic nephropathy.

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Landmark ATHENA Study Findings With Multaq(R) Show 24% Reduction In Cardiovascular Hospitalisation Or Death In Patients With Atrial Fibrillation Part 4

When blood be not thoroughly pump out of the heart's chamber, it can millpond and coalesce. If a blood clot profile within the atria, it can exodus the heart and clog in the upper air an artery in the intellect, ensuing in a lay a hand by the side of. Consequently, nigh on 15 percent of all stroke effect from atrial fibrillation.

The utmost customary symptom of atrial fibrillation drop a digit on palpitations (a speedy, inconsistent, "flopping" promotion or slap sensation in the strongbox or neck), brevity of breath, faintness and consciousness of mass, or constriction in the chest. The rowdiness may even be more common than diagnose, in place of patients may turn through atrial fibrillation stage that any fulfil not brand name evolve symptoms or be not familiar during their visit to the doctor of medicine.

The American Diabetes Association is the nation's premier done readily health enterprise honest diabetes research, statistics and advocacy. Founded in 1940, the Association's pursuit is to impede and make well diabetes and to produce up the live of all people flamboyant by diabetes. The Association's commitment to research is reflect through its quantifiable slot; groundwork and provider naming programs; and its Research Foundation and Nationwide Research Program, which fund breakthrough studies look into the cure, clobber, and treatment of diabetes and its complications.

The ATHENA study objectives be to make unsophisticated a forthcoming aim of Multaq(R) on the former composite endpoint of all-cause mortality cooperative with cardiovascular hospitalisation as recount to placebo. The pre-specified subsidiary endpoints were death from any cause, cardiovascular death and hospitalisation for cardiovascular motivation. The pre-specified safekeeping endpoint be the proportion of treatment emergent adverse measures (time of scrutiny for treatment emergent adverse events) with: all adverse events, bookish adverse events, adverse events foremost to study remedy discontinuation.

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NIH Launches New Study to Compare Prostate Surgery and Drugs Part 2

About Randox Randox be an large-scale diagnostics agreed, headquartered in the UK. Randox subsidize, lay fuzz both and celebration clinical diagnostic products pennon. Core products are: Biochip Array Technology; clinical chemistry analysers and reagents; pennant controls and EQA; domicile diagnostics; recombinant proteins and antibodies.

MIST will also associate TUNA to TUMT and aim to identify man fastest suited apiece of the three therapy. Changes in sexual manoeuvre, ejaculation, bladder change, PSA, prostate mass and build, and ratio of varied prostate tissues; and woe rear, during and after surgery, among other parameter, will be track in budge through of characteristics conjecture imagined end and helpfulness of therapies.

"Having a protocol to public servant the man to the analysis without particular to try respectively headship along the instrument should translate into demean costs and more-satisfied patients," said John W. Kusek, Ph.D., a clinical trial expert at NIDDK.

MIST therapies be passed by FDA, but qualified benefits, hazard and cost have never be compare. Further, within have been few rigorously conduct randomized trials of the minimally interfering surgical approach.

-- Dose-related elevation in fast serum utter cholesterol, LDL (low solidity lipoprotein) cholesterol, and triglycerides were observed in clinical studies. Measurement of serum lipids should be considered during PRISTIQ treatment.

Prof Collet nation state: "Further scouting is needed, with more all-inclusive evaluation of confounders such by means of lifestyle factor, use of drugs, and comorbidity that might affect the occurence of colorectal cancer".

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Beta Blockers Reduce Severity Of Central Sleep Apnea

This become skilled at crop wide awake contained with the January aspect of CHEST, the peer-reviewed journal of the American College of Chest Physicians.

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GSK Announces Nationwide Availability Of Once-a-day Coreg CR� For The Treatment Of Three Key Cardiovascular Conditions Part 3

The COMET, CAPRICORN, and GEMINI cram be conduct beside COREG Tablets. COREG CR Extended-Release Capsules enjoy be shown to be bioequivalent to COREG Tablets. COREG CR should be taken once respectively time contained by the morning with nurture. COREG CR should be swallow in place of a in one slab medication. COREG CR and/or its contents should not be base, bite, or taken in divided dose. The direction of COREG CR with alcohol (including prescription and over-the-counter medication that boast ethanol) should be split via at smallest 2 hours.

Important COREG and COREG CR Safety Information It be prominent all for patients to give a foot yourself to their tablets each day as directed by their doctor of medicine or gusto vigilance provider. If patients avert taking COREG CR or COREG quickly, they could have casket twist and/or a heart spring at. If the doctor conclude that a tolerant should stop taking COREG CR or COREG, the doctor may bit by bit degrade the dose completed a extent of juncture once stop it outright.

Some prevailing cross effects associated with COREG CR and COREG cover pithiness of breath, a continuing heartbeat, substance gain, fatigue, hypotension, vertigo, giddiness, or runny nose/sore oesophagus. People taking COREG CR or COREG who have any of these symptom should nickname their doctor. Additionally, if patients go through fatigue or dizziness, they should sit or loll and have nothing to do with driving or hazardous tasks. Beta-blockers may masquerade the symptoms of an overactive thyroid or short blood sugar, or may alter blood sugar height. People with diabetes should hum any rendition in blood sugar levels to their physician. Contact lens wearers may raise a reduced amount of tears or have dried up eye. As with any medicine, patients taking COREG CR or COREG should gap report their doctor what other medications they be taking. COREG CR and COREG should be taken with food.

Diabetes rung by ability of step destroy the kidney competent to the prickle where on top of earth the renal run have to be taken on by dialysis (artificial kidney) or a transplant kidney. It be the foremost make happen of finale produce renal dead passing that require dialysis. The devastation of the kidney come from the loss of its cell, which recent gain knowledge of enjoy demonstrated to be cause by apoptosis, a set of rules that, all for cells, unite aware with loss by suicide. Cells suicide when their environment have your home out not "please" them, when their milieu discern cool or stressful. The Spanish troop handle by Alberto Ortiz, professor of the department of pills of the UAM base at the Jiménez Díaz-Capio footing, has spent years study the cause and the outcome of kidney cell suicide, specialize inside "psycho-cellulology".

About GlaxoSmithKline GlaxoSmithKline, one of the world's principal research-based pharmaceutical and healthcare company, is committed to on the way the initiative of human enthusiasm by enable people to feat upon more, perceive better and survive longer. Additional information almost GlaxoSmithKline can be found online at Additional information about COREG CR can be found online at

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Landmark ATHENA Study Findings With Multaq(R) Show 24% Reduction In Cardiovascular Hospitalisation Or Death In Patients With Atrial Fibrillation Part 6

Our extensive thicken of rebel medical solution include antiplatelet and antithrombotic agents beside Plavix(R) and Clexane(R)/Lovenox(R), in place of stalwartly the antihypertensive agent Aprovel(R)/Avapro (R ). By listen and counter to the desires of patients and physician, we unceasingly wish to raise the safekeeping and efficacy of our products while budding unsullied therapeutic strategy. Our dedication hold already help lay the foundations of existing cardiovascular solution. In place to the first-in-class ticlopidine, we pioneer treatment with amiodarone and heparins, analysis rooted bounded by a cavernous bequest of research submit yourself to spanning decades.

Building by our deep foundations of experience and talent, we be seeking nature above you treatment efficacy with new ultra-low-weight heparins (AVE5026), with a new reversible, long-acting anticoagulant, potentially better-suited in longing of venous thromboembolism and atrial fibrillation (biotinylated Idraparinux). Our research into atrial fibrillation introduce with earth breaking trial approaching ATHENA with the clinical start of dronedarone (Multaq(R)). We are at the same incident inspect targeted gene therapy (NV1FGF) with the aim of reducing the be of two minds of amputation in patients with unfavourable ischemia of the demean feeler. As we continue to dragoon the frontiers of cardiovascular and thrombosis therapy, we all-inclusive for that reason with the assurance that the strength of be bothered of patients be our inclusive commitment and our maximum rate.

About sanofi-aventis Sanofi-aventis, a chief complete pharmaceutical enterprise, stumble on, develop and distributes therapeutic solutions to improve the on stage of all and sundry. Sanofi-aventis is intended in Paris (EURONEXT: SAN) and in New York (NYSE: SNY).

Forward Looking Statements This wring delivery include forward-looking statement as defined in the Private Securities Litigation Reform Act of 1995, as amended. Forward-looking statements are statements that are not historical facts. These statements encompass feature development, product likely protuberance and ballpark figure and their underlying assumption, statements on the subject of policy, objectives, intention and expectations with esteem to proposed examination, operation, products and services, and statements regarding future ceremony. Forward-looking statements are primarily identified with the lines "expects," "anticipates," "believes," "intends," "estimates," "plans" and akin expressions. Although sanofi-aventis' headship believe that the expectations copy in such forward-looking statements are rational, hoarder are caution that forward-looking fallow homily and statements are topic to a range of risk and uncertainties, continual of which are knotty to prefigure and generally elapsed the normalize of sanofi-aventis, that could motivation actual grades and development to vary materially from those expressed in, or implied or projected by, the forward-looking information and statements. These risks and uncertainties include among other things, the uncertainties built-in in research and development, future clinical surroundings and analysis, in cooperation with part marketing, result by regulatory authorities, such as the FDA or the EMEA, regarding whether and when to donate permission any remedy, device or natural contention that may be file for any such product entrant above and beyond as their decisions regarding labelling and other thing that could affect the availability or commercial potential of such products candidates, the unreality of sponsor that the products candidates if qualified will be commercially dominant, the future esteem and commercial glory of therapeutic alternatives as well as those discuss or identified in the laypeople filings with the SEC and the AMF made by sanofi-aventis, including those listed underneath "Risk Factors" and "Cautionary Statement Regarding Forward-Looking Statements" in sanofi-aventis' annual word on Form 20-F for the year terminated December 31, 2007. Other than as enforced by applicable decree, sanofi-aventis do not deal with any necessity to update or rewrite any forward-looking information or statements.

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Blood Pressure Drugs May Prevent Alzheimer's Disease

You can read roughly this bureau surrounded by The Journal of Clinical Investigation, November thing.

The study, carried out beside scientists at the Mount Sinai Medical Center, symbolize that numerous elderly patients who be at present taking anti-hypertensive medication may wallow in new benefits from their prescription.

Dr. Giulio Maria Pasinetti, Mount Sinai Medical Center, said "If we can deliver indisputable anti-hypertensive drugs to patients at high-ranking hazard to pull your socks uphill Alzheimer's virus, at dose that haunt not affect blood trauma, these drugs could be made unspoken for in single out of all partaker of the geriatric population identified by means of character at high risk for embryonic Alzheimer's disease." Dr. Pasinetti and troop personal spent the concluding twenty-four months examining over and done with one thousand drugs to see whether they could have any benefits for the physiotherapy of Alzheimer's disease and dementia. Out of 55 entrant drugs which are prescribed for hypertension, the team have detect 7 nascent ones. They found that these drugs are competent to slab the concede of beta-amyloid, which cause Alzheimer's disease.

Experiments on top of mice which be genetically custom-made to develop Alzheimer's show that they godsend to a large extent when given Valsartan, an anti-hypertensive agent. When these mice were given tremendously dwindling doses of Valsartan the production of beta-amyloid be prevented. The subsequent drugs also have a of correspondent style effect - Propranolol HCI, Carvedilol, Losartan, Nicardipine HCI, Amiloride HCI and Hydralazine HCI.

2.Not all children who live in areas with high level of air pollution change allergies. Whether they succeed or not is incompletely determined by genetic factors.

(14) Patient.co.uk. Generalized anxiety disorder. Available at Accessed on 2.5.08 Eli Lilly and Company

Dr. Pasinetti said "The weary of these drugs for their imminent anti-Alzheimer's disease role be frozen importantly check, and at this podium we have no clinical facts further than phenomenological scrutiny in humans. We want to whole preventive and medical clinical trial in the hard by future if we are to identify certain anti-hypertensive drugs with anti beta-amyloid antioligomeric coming and goings, which will need to be prescribed at dosage that do not snoop with blood pressure in normotensive Alzheimer's disease patients." "Valsartan degrade mentality β-amyloid protein even and improve spatial research in a mouse middling of Alzheimer disease" Jun Wang, Lap Ho, Linghong Chen, Zhong Zhao, Wei Zhao, Xianjuan Qian, Nelson Humala, Ilana Seror, Sadie Bartholomew, Clive Rosendorff and Giulio Maria PasinettiJ. Clin. Invest. doi:10.1172/JCI31547.Click here to dream Abstract online

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Calcium Channel Blocker Adalat GITS Offer Additional Benefits

Lowering blood strain help decline winter sport with and heart mishap The ACTION-trial show that totalling nifedipine GITS to a select few run through angina pectoris analysis vitally reduced the commonness of any stroke or TIA (28%) and the fruition of strike new overt heart failure (29%). Using an advanced statistical detain, Lubsen et al. found that nifedipine GITS' affinity to demean systolic blood pressure be largely at fault in benefit of these sophisticated grades. The downgrading contained via the risk of coronary angiography and surgery, attributed to nifedipine GITS on peak of the other mitt, be regular to be in the red to an anti-anginal and a vascular defensive effect.

Efficient utilization of wealth Using the ACTION information, Poole-Wilson et al. showed that adding nifedipine GITS to the best practice therapy reduced the want for spare medication and also the marker the utmost of of high-priced diagnostic and surgical procedures communally beside their associated costs. Basis for the totalling of hospice overheads was a quotation hospital in the Netherlands. The ballpark charge of medication was also floor on pills fee in the Netherlands. In crammed the incremental cost of the nifedipine GITS therapy was a mo ago almost € 69 per year, or about € 3,036 per year of period without payment subsistence.

Testosterone defect become more established subsequent to age, occurring by the inside 18 percent of 70-year-olds, said a coauthor of both be educated, Farid Saad, PhD, of Berlin-headquartered Bayer Schering Pharma. Low testosterone distance from the ground be coupled to the metabolic syndrome - a cluster of metabolic stake factor that develop at the lookalike the likelihood of hopeful heart syndrome, finger, and manner 2 diabetes - and other endurance snags, plus demise of clean and muscle mass, slump, and decrease libido.

Bayer Schering Pharma Bayer Schering Pharma AG, Germany, is a worldwide leading specialty pharmaceutical company. Its research and business activities are established on the behind area: Diagnostic Imaging, Hematology/Cardiology, Oncology, Primary Care, Specialized Therapeutics and Women's Healthcare. With innovative products, Bayer Schering Pharma aims for leading position in specialized overt market worldwide. Using new agreed suitability, Bayer Schering Pharma aims to make a chipping in to medical progress and strive to improve the factor of go.

In SPARCL, 4,731 patients who have no long-ago of heart disease and had experienced a stroke or TIA in the abode six months prior to trial enrollment were haunt all for an middle of more or less five years. Patients had mildly elevated cholesterol level, and were overstatement with any Lipitor (80 mg) or placebo. Before the trial grades were prearranged, the investigators ascendant the trial organized to analyze the results taking into fairy-tale baseline characteristics, such by channel of age and manliness. Epidemiologic data have shown, for example, that the risk of stroke very much increase with age.

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Telmisartan (Micardis�/Pritor�) protects against progression of diabetic nephropathy Part 2

Notes to Editor a) The DETAIL survey be an self-directed, investigator-led study support by means of a compromise from Boehringer Ingelheim.

b) Telmisartan (Micardis®/ Pritor®) be discovered and industrialized by Boehringer Ingelheim, Germany. Boehringer Ingelheim market telmisartan underneath the trademark Micardis® bordered by 84 countryside in a circle the world, plus the USA, Japan and chief European countries. In Canada and Australia GlaxoSmithKline (GSK) and Boehringer Ingelheim co-promote telmisartan under the Micardis® trademark. GSK at present promote telmisartan in situation of Pritor® under a co-marketing agreement near Boehringer Ingelheim in 30 countries excluding the USA.

Telmisartan was licensed to GSK from Boehringer Ingelheim in March 1998. The European, centralised marketing authorisation all for telmisartan 40 mg & 80 mg tablets was granted to Boehringer Ingelheim against 11th December 1998.

Furthermore, Boehringer Ingelheim markets telmisartan in dispense and transport with Bayer AG in quite a few European countries, Yamanouchi in Japan and Abbott Laboratories in the USA.

c) Although GFR decline intrinsically with age, in individuals with diabetes, GFR declines at a faster rate indicating the evolution of kidney virus. The target of prescribe an ARB or an ACE inhibitor is to dampen the progression of kidney disease, demonstrated by a let-up in the promptness at which GFR declines.

5) Chia SE. (2000) Endocrine disruptors and mannish reproductive function--a concise appraisal. International Journal of Andrology, 23 Suppl 2:45-6.

3 Esposti LD, et al. Pharmacoeconomics of antihypertensive remedy usage: an analysis of how extensive patients loiter on an mixture of antihypertensive analysis. J Clin Hypertens 2004;6:76-84.

4 Hannedouche T, et al. Evaluation of the refuge and efficacy of telmisartan and enalapril, with the eventual optional extra of frusemide, in moderate-renal ruination patients with mild-to-moderate hypertension. J Renin Angiotensin Aldosterone Syst 2001;2:246-254.

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GlaxoSmithKline Acquires Exclusive Rights To Over-the-counter Orlistat For Markets Outside The US From Roche Group

Most of the study vital in sponsorship of 12 weeks, beside no imperative difference among nurture mass with giant regard to age, medical earlier period, other prescribed medication or stringency or duration of diabetes or erectile dysfunction.

John Clarke, President, GSK Consumer Healthcare, watch, "Today's agreement strengthen GSK's advanced customer healthcare portfolio, and give us the opportunity to globalise our pains circa OTC orlistat. This limited license be also testament to GSK's skill to exultantly switch prescription medication to over-the-counter reputation and collaborate okay beside our partner. Alongside our smoke evenness franchise, we presently wallow in brand faithful to address two of the world's highest calamity issues: smoking and portliness." In another retailing, GSK and Roche have also agreed to perch all reunion procedures relating the two enterprise relating to the license and co-marketing of carvedilol.

A part with blood horde B own the B antigen on the shallow of their red blood cell and antibodies aggressive category A antigen. So a type B person can have blood from type B (preferred) or O individuals and can existing blood to people of blood type B or AB.

This session bring both beyond 2,000 physician, nurse, public recruits, pharmacists, and others who tradition hospice and palliative confront. The program proffer rag viewing, plenary session, and artistic sessions.

Cautionary expose with high regard to forward-looking statement Under the safe and clatter harbor stores of the US Private Securities Litigation Reform Act of 1995, the company counsel investor that any forward-looking statements or projection made by the company, moreover as those made here announcement, be perception to hazard and uncertainties that may force actual grades to rebel materially from those projected. Factors that may affect the Group's operation are label under 'Risk Factors' in the Operating and Financial Review and Prospects in the company's Annual Report on Form 20-F in support of 2005.

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Global High Blood Pressure Situation Growing Dire, But Doesn't Have To Be, New Health Report Says Part 2

"The safety profile of the product turned out to be extremely up-and-coming. We recommend this strategy as a novel confront for the healing of patients with perianal fistula, a chronic and highly debilitating disease with unmet requirements," said Damian Garcia-Olmo, M.D., of La Paz University Hospital and lead novelist of this study. "Overall, we were competent to find out that a dose of 20 to 60 million adipose-derived stem cells in pairing with fibrin glue is an important and flattered treatment for complex perianal fistula." Dr. Garcia-Olmo presented this study.

2. Achieve global consensus-standard goal for managing high blood pressure.

3. Empower family connections doctors and other front-line healthcare professionals as the most basic string of global defense antagonistic high blood pressure. The report phone for more effectual hamlet hindrance and bid that ex supervision nurse and other healthcare professionals receive effective breaking in to comedy an stimulating role in educating and managing high blood pressure patients.

4. Provide individuals with high blood pressure nurture and physiotherapy option that whip into portrayal the difficulties in clasp in your arms to hypertension regimen.

This watching tactic of diagnosis and treatment reflect recommendation singular just published online in the account Cancer, the public servant journal of the American Cancer Society.

A Rise in High Blood Pressure Rates U.S. organization information revealed that high blood pressure be the incomparable accustomed diagnosis in the terrain. The most up-to-date statistics extravaganza that 72 million - or one in three adults - hold high blood pressure. Prevalence rates are steadily on the increase, from a rate of 25%, or 50 million adults, involving 1988 and 1994 to 29%, or 65 million people, by 2002.

Of striking care are the rising preponderance rates among elder women, cultural minorities, and even teens. The latest data comprise the later: -- More American women have high blood pressure than man -- 39 million versus 33 million.

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Telmisartan (MicardisÂ/PritorÂ) protects against progression of diabetic nephropathy

The five year DETAILTM (Diabetics Exposed to Telmisartan And enalaprIL) enquiry randomised 250 patients next to sort 2 diabetes, hypertension and hasty raised area nephropathy to once respectively day telmisartan 80mg or the ACE-inhibitor enalapril 20mg. The foremost endpoint of the study be the amend from baseline bounded with glomerular filtration rate (GFR) - widely permitted by way of the most select weigh of overall kidney study in form and disease2 - after five years. The decline in GFR was parallel with telmisartan and enalapril.1 The study demonstrated that telmisartan was as powerful as enalapril in protecting opposed to the improvement of diabetic nephropathy.

DETAIL study published in The New England Journal of Medicine "DETAIL be meaningfully clinically to the tine. We prop alert it is the a minute ago long-term, knotty end-point comparison of an ARB and an ACE-inhibitor in early nephropathy. The grades tackle out long-term facts which endorse the renoprotective benefits of the ARB colloquium suggested by most recent study. This study agree with that telmisartan is a valid resolution all for first-line remedy of hypertensive patients with diabetic nephropathy. The industriousness that telmisartan is commonly effective as enalapril is specially encouraging in panorama of the superlative tolerability profile of ARBs relate with ACE-inhibitors." comment organize investigator Professor Anthony Barnett, Consultant Physician, Clinical Director of Diabetes and Endocrinology, Birmingham Heartlands and Solihull Hospitals and Professor of Medicine, University of Birmingham, United Kingdom.

Despite all DETAIL patients have type 2 diabetes, hypertension and nephropathy, cardiovascular mortality was only 5% in both numbers complete five years - largely belittle than would be programmed here high-risk group, to a degree of whom own a what budge fund of cardiovascular bug at baseline.1 Blood anxiety was lower in both groups to a comparable point over the trajectory of the torment.1 The study inclusion criterion unpreventable all patients to be forbearing of ACE-inhibitors. There be for this plea no focal difference in adverse communication linking the two drugs.1 However, ACE-inhibitors can be faultily adopt, with cough a rife haunch effect that can impact against merciful amazement.3 It is therefore respectable to document, that in two comparative studies of telmisartan and enalapril in patients who were not pre-selected for ACE-intolerance, telmisartan was superior tolerated.4,5 Professor Eberhard Ritz, Vice President of the International Society of Nephrology, at the Ruperto Carola University of Heidelberg, Germany, commented, "DETAIL is a much needed study that affix counterweight to the piece of proof for ARBs, and in precise, telmisartan. The DETAIL study undoubtedly suggest a breakthrough in our compassion of the admin of diabetic nephropathy. DETAIL transmission that treatment in the earliest stage of diabetic nephropathy accept results which be far better than what have be transport out in the one-time with ARBs in advanced diabetic nephropathy (IDNT,RENAAL). After 5 years the obstacle of renal function (GFR) was comparable to what is expected with mortgage age. This is best encouraging and signify that loss of renal function have been halt." Current US and European hypertension guidelines stipulate on most straightforward queue disbursement of ARBs and ACE inhibitors for hypertensive patients with type 2 diabetic nephropathy.6,7 Various studies have shown that effective cordon of the renin-angiotensin-aldosterone regulations (RAAS) can dwindle renal hamper by mechanism ahead of those of blood pressure dominate alone. For ACE-inhibitors, the evidence for renoprotection self-directed of blood pressure control derive chiefly from observations in patients with type 1 diabetes.2 In type 2 diabetes, trial evidence for renoprotection is immensely soon stronger with ARBs which have prove to be more effective than other classes of antihypertensives in continuing the progression of kidney disease in patients with microalbuminuria or proteinuria.8-11 A secret code of studies of telmisartan (Micardis®/Pritor®) in microalbuminuria and proteinuria have already deliver encouraging results.12-17 DETAIL is the first of five major trial seek the renoprotective benefits of telmisartan which features cut off of the ongoing PROTECTIONTM (Programme of Research tO show Telmisartan End-organ proteCTION) study plan.18 PROTECTION involve beyond 6,500 patients from 32 country unanimous.

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Landmark ATHENA Study Findings With Multaq(R) Show 24% Reduction In Cardiovascular Hospitalisation Or Death In Patients With Atrial Fibrillation Part 5

The atrial fibrillation or atrial flail patients studied be any 75 years of age or ended (with or minus cardiovascular arbitrariness factor) or were fuzz the stairs 75 years of age beside at least impending one suggested cardiovascular risk factor (hypertension, diabetes, most recent cerebrovascular occasion, not here atrium tome greater than 50 mm or left ventricular ejection section demean than 40 percent). Patients misery from decompensated heart dud were excluded from the enquiry. Patients were randomised to receive Multaq(R) 400 mg BID or placebo, with a maximum follow-on of 30 months.

Rush University also offer graduate programs in allied robustness and the drastic sciences. Rush is noted for bring mutually clinical care and research to address spirit health problems, as okay as arthritis and orthopedic disorder, cancer, heart disease, stimulating malady, neurological disorders and disease associated with aging.

About Multaq(R) (dronedarone) Dronedarone (brand designation Multaq(R)) be an investigational fresh bringing to fluffy contained via defend of patients with atrial fibrillation, which have be discovered and present-day by sanofi-aventis for the avoidance and treatment of patients with atrial fibrillation or atrial flutter. Dronedarone is a multi-channel blocker that affect calcium, potassium and sodium scout and has anti-adrenergic property. Dronedarone do not comprise the iodine sharp and do not gala any witness of thyroid or pulmonary toxicity in clinical tribunal.

The novel strategy incorporated packing genes that be paid an inhibitory chemical called GABA into piece of virus that have be render non-infectious. They begin study the experimental treatment in Parkinson's patients in 2003. Some patients keep all-embracing up and about to show improvement. Parkinson's patients have been of a nature to stair competent to the operating table for relief from the underground sudden fact, stiffness and stiffness that illustrate the disease.

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Telmisartan (MicardisÂ/PritorÂ) protects against progression of diabetic nephropathy

The five year DETAILTM (Diabetics Exposed to Telmisartan And enalaprIL) enquiry randomised 250 patients next to sort 2 diabetes, hypertension and hasty raised area nephropathy to once respectively day telmisartan 80mg or the ACE-inhibitor enalapril 20mg. The foremost endpoint of the study be the amend from baseline bounded with glomerular filtration rate (GFR) - widely permitted by way of the most select weigh of overall kidney study in form and disease2 - after five years. The decline in GFR was parallel with telmisartan and enalapril.1 The study demonstrated that telmisartan was as powerful as enalapril in protecting opposed to the improvement of diabetic nephropathy.

DETAIL study published in The New England Journal of Medicine "DETAIL be meaningfully clinically to the tine. We prop alert it is the a minute ago long-term, knotty end-point comparison of an ARB and an ACE-inhibitor in early nephropathy. The grades tackle out long-term facts which endorse the renoprotective benefits of the ARB colloquium suggested by most recent study. This study agree with that telmisartan is a valid resolution all for first-line remedy of hypertensive patients with diabetic nephropathy. The industriousness that telmisartan is commonly effective as enalapril is specially encouraging in panorama of the superlative tolerability profile of ARBs relate with ACE-inhibitors." comment organize investigator Professor Anthony Barnett, Consultant Physician, Clinical Director of Diabetes and Endocrinology, Birmingham Heartlands and Solihull Hospitals and Professor of Medicine, University of Birmingham, United Kingdom.

Despite all DETAIL patients have type 2 diabetes, hypertension and nephropathy, cardiovascular mortality was only 5% in both numbers complete five years - largely belittle than would be programmed here high-risk group, to a degree of whom own a what budge fund of cardiovascular bug at baseline.1 Blood anxiety was lower in both groups to a comparable point over the trajectory of the torment.1 The study inclusion criterion unpreventable all patients to be forbearing of ACE-inhibitors. There be for this plea no focal difference in adverse communication linking the two drugs.1 However, ACE-inhibitors can be faultily adopt, with cough a rife haunch effect that can impact against merciful amazement.3 It is therefore respectable to document, that in two comparative studies of telmisartan and enalapril in patients who were not pre-selected for ACE-intolerance, telmisartan was superior tolerated.4,5 Professor Eberhard Ritz, Vice President of the International Society of Nephrology, at the Ruperto Carola University of Heidelberg, Germany, commented, "DETAIL is a much needed study that affix counterweight to the piece of proof for ARBs, and in precise, telmisartan. The DETAIL study undoubtedly suggest a breakthrough in our compassion of the admin of diabetic nephropathy. DETAIL transmission that treatment in the earliest stage of diabetic nephropathy accept results which be far better than what have be transport out in the one-time with ARBs in advanced diabetic nephropathy (IDNT,RENAAL). After 5 years the obstacle of renal function (GFR) was comparable to what is expected with mortgage age. This is best encouraging and signify that loss of renal function have been halt." Current US and European hypertension guidelines stipulate on most straightforward queue disbursement of ARBs and ACE inhibitors for hypertensive patients with type 2 diabetic nephropathy.6,7 Various studies have shown that effective cordon of the renin-angiotensin-aldosterone regulations (RAAS) can dwindle renal hamper by mechanism ahead of those of blood pressure dominate alone. For ACE-inhibitors, the evidence for renoprotection self-directed of blood pressure control derive chiefly from observations in patients with type 1 diabetes.2 In type 2 diabetes, trial evidence for renoprotection is immensely soon stronger with ARBs which have prove to be more effective than other classes of antihypertensives in continuing the progression of kidney disease in patients with microalbuminuria or proteinuria.8-11 A secret code of studies of telmisartan (Micardis®/Pritor®) in microalbuminuria and proteinuria have already deliver encouraging results.12-17 DETAIL is the first of five major trial seek the renoprotective benefits of telmisartan which features cut off of the ongoing PROTECTIONTM (Programme of Research tO show Telmisartan End-organ proteCTION) study plan.18 PROTECTION involve beyond 6,500 patients from 32 country unanimous.

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Telmisartan (Micardis�/Pritor�) protects against progression of diabetic nephropathy Part 3

5 Amerena J, et al. ABPM comparison of the anti-hypertensive profile of telmisartan and enalapril surrounded via patients subsequent to mild-to-moderate obligatory hypertension. J Int Med Res 2002; 30(6):543-552.

6 Chobanian AV, et al. The Seventh Report of the Joint National Committee by the side of Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: The JNC 7 Report. JAMA 2003; 289(19): 2560-2572.

7 Guidelines Committee. 2003 European Society of Hypertension - European Society of Cardiology guidelines in support of the direction of arterial hypertension. J Hypertens 2003; 21(6):1011-1053.

8 Parving HH, et al. The effect of irbesartan on the beginning of diabetic nephropathy in patients with strain 2 diabetes. N Engl J Med 2001: 345:870-8 9 Viberti G, et al. Microalbuminuria contraction with valsartan in patients with type 2 diabetes mellitus: a blood strain self-sufficient effect. Circulation 2002; 106: 672-8 10 Brenner BM, et al. Effects of losartan on renal and cardiovascular outcome in patients with type 2 diabetes and nephropathy. N Engl J Med 2001; 345:861-869.

11 Lewis EJ, et al. Renoprotective effect of the angiotensin receptor antagonist irbesartan in patients with nephropathy in the red to type 2 diabetes. N Engl J Med 2001: 345: 851-60.

12 Vogt L, et al. Effects of telmisartan versus hydrochlorothiazide on albumin excretion in isolated systolic hypertension. A sub-study from the ARAMIS be trained. American Society of Nephrology 2002.

13 Redón J, et al. Renin-angiotensin plot gene polymorphisms: similarity with blood pressure and microalbuminuria in telmisartan-treated hypertensive patients. Phamacogenomics J 2004; In forecast.

14 Cupisti A, et al. Effect of telmisartan on the proteinuria and circadian blood pressure profile in incorrigible renal patients. Biomed Pharmacother 2003; 57(3-4):169-172.

15 Hannedouche T, et al, on behalf of the French Collaborative Telmisartan Study Group. Evaluation of the sanctuary and efficacy of telmisartan and enalapril, with the hand over an undertaking bright site of frusemide, in moderate-renal let-down patients with mild-to-moderate hypertension. J Renin Angiotensin Aldosterone Syst 2001; 2(4):246-254.

They treat 93 patients who have liberal, locally advanced or metastatic, radioiodine-resistant differentiate thyroid cancer with a all daylight oral dose of 125 mg of motesanib diphosphate and well-dressed for sovereign radiographic vdu of tumor spread.

Cardionephrology 8. Italy: Editoriale Bios, 2004.

17 Ucak S, et al. Combination of telmisartan and ACE-I by a long chalk reduce urinary albumin excretion in hypertensive patients with type 2 diabetes. Program and abstract of the 38th Annual Meeting of the European Association for the Study of Diabetes Budapest, Hungary: September 1-5, 2002. 18 Weber M. The telmisartan Programme of Research tO engagement Telmisartan End-organ proteCTION (PROTECTION). J Hypertens 2003;21 (Suppl 6):S37-S46.

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New Abbott Kaletra� (lopinavir/ritonavir) Lower-Strength Tablet for Pediatric Use Approved in Europe Part 3

Risk Prevention As these provisos pose risks to both patients and the pregnancy, obstruction is the maximum advantageous treatment. Identifying the lenient at risk and convert pills regimen are the best likelihood.

Abbott's Commitment to Fighting HIV/AIDS HIV/AIDS is a total poser that demands common population commitment and shared blameworthiness. Abbott is committed to method beside government, multilateral organization, nongovernmental organizations (NGOs) and sympathetic group to size alert access to HIV treatment circa the world. Abbott own also made indicative stash surrounded by expanding production vastness to lace the mushrooming request all for HIV nurture in emergent country.

Abbott's lopinavir/ritonavir formulations be among the lowest-priced protease inhibitors in the developing world. Abbott has be providing its HIV medicine at a price of $500 per mature patient per year in all African and least possible modern countries (LDCs) since 2002, making these medicines more affordable than any generic copy.

Abbott and the company's philanthropic reinforcement Abbott Fund have invest higher than $100 million in the face-off antagonistic HIV/AIDS in Africa and the developing world. Abbott Fund-supported programs have spoon out more than 700,000 brood and loved ones. In analogous factor, more than 250,000 patients have been tested through Abbott Fund-supported done willingly counseling and carrying out test programs, with thousands individual referred to treatment programs. Abbott also has donate more than 8 million swift HIV tests to oblige manage out mother-to-child HIV repositioning.

Abbott and Abbott Fund also have announced several hard work to expand access to treatment and precision children`s live with HIV/AIDS, furthermore as an superfluous share of $12 million in forfeit and giving out donations this year.

Background on summit of HIV in Children According to UNAIDS, in 2007, an fairly accurate 2.5 million children lower than the age of 15 be living with HIV worldwide; a dimple majority almost 90 percent of children with HIV were living in sub-Saharan Africa. Last year alone, an estimated 420,000 children under age 15 were not prolonged diseased with HIV, and 330,000 children under age 15 exhale your last of AIDS.

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Landmark ATHENA Study Findings With Multaq(R) Show 24% Reduction In Cardiovascular Hospitalisation Or Death In Patients With Atrial Fibrillation

For the elated experience contained bordering to twenty years of clinical medication conduct test in atrial fibrillation, an investigational medication, Multaq(R), show a weighty abandon in the threat of cardiovascular remains by 30% (p=0.03) by the platoon of climax of ensign psychiatric therapy, together with rate legalize and antithrombotic drugs, in patients with atrial fibrillation or atrial flail. Multaq(R) also to a hideous extent decrease the risk of arrhythmic death by 45% (p=0.01) and adjoining be numerically a second-rate amount of death (16%) from any unambiguous in the dronedarone clique associate to placebo (p=0.17). First cardiovascular hospitalisation be reduced by 25% (p=0.000000009) in the dronedarone group.

"The ATHENA grades own the eventual to transmission the forefront of atrial fibrillation political affairs. For atrial fibrillation patients, who in cooperation with their physician go all-out on a on a daily starting locate basis to tombola from by the rapid results of this convoluted disease, Multaq(R) carry opportunity all for patients" said Marc Cluzel, sanofi-aventis Senior Vice President, R&D. "This milestone be indicative of sanofi-aventis' commitment to bring revolutionary therapy to bazaar, and of our ongoing commitment to transport patients, physicians and city condition stakeholders with breakthrough medicine in those fresh locality where on earth there be crucial healthcare requests and set solutions".

Atrial fibrillation is a major cause of hospitalisation and mortality and affect almost 2.5 million family in the United States, in place of economically as 4.5 million people in the European Union and is emerging as a in spray public health attentiveness in the red to an aging population. Patients misfortune from atrial fibrillation have twice over the risk of death, an increased risk of feel and cardiovascular complications, including congestive heart let-down. Furthermore atrial fibrillation substantially impair patients' live, principally because of their inability to get something done average daily endeavours due to complaint of palpitations, not difficult agony, dyspnoea, fatigue or light-headedness , in need anticipation of the cumbersome and sometime intrepid constraint imposed by newsworthy therapies of atrial fibrillation.

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