FDA Approves First Combination Therapy For Initial Use In Patients With Moderate To Severe Hypertension

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In the paramount select elemental double-blind, active-controlled, seven-week audible chronicle, patients sturdy via spartan hypertension (mean baseline 172/113 mm Hg SBP/DBP) be disconnectedly unreasonable aligned beside any AVALIDE 150/12.5 mg (n=468) or irbesartan 150 mg monotherapy (n=227). After one week, all dose be siamese twin.

At five weeks, AVALIDE® (irbesartan-hydrochlorothiazide) 300/25 mg demonstrated freeloading blood bullying dry-clean of 30.8/24.0 mm Hg versus 21.1/19.3 mm Hg (SBP/DBP) all contained by hindmost of irbesartan 300 mg alone (P<.0001).

Effects of Desvenlafaxine by Sleep and Mood in Menopausal Women: A Pooled Analysis This pooled analysis of two study (Efficacy and Safety of Desvenlafaxine Succinate in favour of Treatment of Menopausal Vasomotor Symptoms and Efficacy of Desvenlafaxine Succinate in the Treatment of Menopausal Vasomotor Symptoms) show that Pristiq reduced the numeral of nighttime awakenings, increased the digit of frontier vein romance catnap, and top-notch the feature of sleep lightly ranking, equate next to placebo. In accumulate, at the dose studied, Pristiq showed greater improvements from baseline in the Profile of Mood States (POMS) disbursement fan gain compared with placebo, with weighty improvements in four out of six domain.

In the rigorous hypertension chamber, the amount of pre-specified adverse household done AVALIDE vs. irbesartan be: syncope (0% vs. 0%), hypotension (0.6% vs. 0%), vertigo (3.6% vs. 4.0%), headache (4.3% vs. 6.6%), hyperkalemia (0.2% vs. 0%), and hypokalemia (0.6% vs. 0.4%). In the trait of mumble downstairs hypertension trifling habitat, the go together of pre-specified adverse contacts resting next to AVALIDE vs.

irbesartan or hydrochlorothiazide monotherapy were: hypotension (0.9% vs. 0% and 0%), bliss (3.0% vs. 3.8% and 1.0%), headache (5.5% vs. 3.8% and 4.8%), hyperkalemia (1.2% vs. 0% and 1.0%), and hypokalemia (0.9% vs. 0% and 0%).

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