Comparing The AstraZeneca Investigational Drug AZD6140 To Clopidogrel For Inhibition Of Platelet Aggregation Part 3

About The DISPERSE2 Study The Dose avowal Study evaluate anti-Platelet Effects of AZD6140 vs clopidogRel contained by NSTEMI be a double-blind, double-dummy, parallel interest group, randomised dose confirmation and know-how survey of AZD6140 plus ASA compare subsequent to clopidogrel plus ASA in 990 patients with non-ST elevation acute coronary syndrome. Subjects received day after day aspirin competent to 325 mg preliminary dose, after 75 to 100 mg, and heparin/LMWH and/or GP IIb/IIIa inhibition per luxury physician. They be randomised to receive one of two dose of AZD6140 (90 mg or 180 mg two times daily) or clopidogrel 75 mg once daily in choose of cognisant to 12 weeks. Half of the AZD6140 patients were sub randomised to receive a goods dose of 270 mg while the other partially started psychiatric member of the clergy to with the repairs dose. Patients randomised to clopidogrel received a 300 mg loading dose unless they enjoy be on head of erstwhile clopidogrel therapy with the prospect to supply an second double-blind clopidogrel 300 mg dose pre-PCI (total 600 mg dose). The earliest stop thorn studied was adjudicate inclusive bleeding activities (major plus minor) in the first four reporting weeks.

About Acute Coronary Syndrome (ACS) ACS be an umbrella tenure for stipulations that head to treasure chest headache in the red to poor blood deliver to the heart muscle (acute myocardial ischemia). ACS take in two conditions - unpredictable angina (chest pain with ECG change compatible with ischemia) and heart beat up (non-ST or ST-elevation myocardial infarction). Unstable angina and non-ST segment elevation myocardial infarction details for gruffly 2.5 million sickbay admission macro and be a key cause of mortality and morbidity in Western country.5 AstraZeneca AstraZeneca is a major sophisticated healthcare company affianced in the research, encouragement, construction and marketing of prescription pharmaceuticals and the supply of healthcare services. It is one of the world's prime pharmaceutical guests with healthcare public sale of $23.95 billion and leading position in sales of gastrointestinal, cardiovascular, neuroscience, respiratory, oncology and infectivity products. AstraZeneca is programmed in the Dow Jones Sustainability Index (Global) by way of in biddable health as the FTSE4Good Index.

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