Wednesday, August 20, 2008

Blood Pressure Drugs May Prevent Alzheimer's Disease




You can read roughly this bureau surrounded by The Journal of Clinical Investigation, November thing.



The study, carried out beside scientists at the Mount Sinai Medical Center, symbolize that numerous elderly patients who be at present taking anti-hypertensive medication may wallow in new benefits from their prescription.



Dr. Giulio Maria Pasinetti, Mount Sinai Medical Center, said "If we can deliver indisputable anti-hypertensive drugs to patients at high-ranking hazard to pull your socks uphill Alzheimer's virus, at dose that haunt not affect blood trauma, these drugs could be made unspoken for in single out of all partaker of the geriatric population identified by means of character at high risk for embryonic Alzheimer's disease." Dr. Pasinetti and troop personal spent the concluding twenty-four months examining over and done with one thousand drugs to see whether they could have any benefits for the physiotherapy of Alzheimer's disease and dementia. Out of 55 entrant drugs which are prescribed for hypertension, the team have detect 7 nascent ones. They found that these drugs are competent to slab the concede of beta-amyloid, which cause Alzheimer's disease.



Experiments on top of mice which be genetically custom-made to develop Alzheimer's show that they godsend to a large extent when given Valsartan, an anti-hypertensive agent. When these mice were given tremendously dwindling doses of Valsartan the production of beta-amyloid be prevented. The subsequent drugs also have a of correspondent style effect - Propranolol HCI, Carvedilol, Losartan, Nicardipine HCI, Amiloride HCI and Hydralazine HCI.



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Dr. Pasinetti said "The weary of these drugs for their imminent anti-Alzheimer's disease role be frozen importantly check, and at this podium we have no clinical facts further than phenomenological scrutiny in humans. We want to whole preventive and medical clinical trial in the hard by future if we are to identify certain anti-hypertensive drugs with anti beta-amyloid antioligomeric coming and goings, which will need to be prescribed at dosage that do not snoop with blood pressure in normotensive Alzheimer's disease patients." "Valsartan degrade mentality β-amyloid protein even and improve spatial research in a mouse middling of Alzheimer disease" Jun Wang, Lap Ho, Linghong Chen, Zhong Zhao, Wei Zhao, Xianjuan Qian, Nelson Humala, Ilana Seror, Sadie Bartholomew, Clive Rosendorff and Giulio Maria PasinettiJ. Clin. Invest. doi:10.1172/JCI31547.Click here to dream Abstract online



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1 comment:

Anonymous said...

Hi great information my grandpa has Alzheimer's Disease and He also takes Cialis Online