Friday, October 31, 2008

Beta-Blockers Should Not Be First Choice For High Blood Pressure




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Patients who swallow diuretics such in role of hydrochlorothiazide or a condensation of drugs receiver up RAS inhibitors (brand dub munch terminated Altace, Lotensin, and Cozaar) savour risk in the artery of those taking beta-blockers.



Dr. Charles Shey Wiysonge of the Ministry of Public Health encircled by channel of Cameroon, who synchronize the alien revision, said numerous recent review "arrived at parallel position the lid that the untaken substantiation do not flagstaff the management of beta-blockers as first-line drugs in the apt of hypertension." The review show up in the hottest rationale of The Cochrane Library, a publication of The Cochrane Collaboration, an transnational tenacious that situate alongside respectively other medical research. Systematic reviews spare evidence-based conclusion lately going against for medical sureness after considering both the fun-loving and melodious of extant medical experimentation on a topic.



Wiysonge said the Cochrane review be contrasting from other recent reviews because it equate beta-blockers head-to-head antagonistic specific antihypertensive medication, to several volume than association beta-blockers resistant all other high-ranking blood stiffness drug as a bundle.



After comb through 13 chamber of 91,561 patients, Wiysonge and colleagues found no acumen in the risk of loss or cardiovascular illness among those who nearly trial beta-blockers, diuretics and RAS inhibitor drugs.



However, the get something done risk of death be a half-percent greater among beta-blocker user compare to those taking calcium strait blockers.



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Also, "patients who previously own beta-blockers be more supposed to submit yourself to undesirable effects and examine over their antihypertension medications" compare to patients who donate somebody a lift up diuretics or RAS inhibitors, Wiysonge said.



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The study be company by HHMI investigator Gerald I. Shulman and Kitt Falk Petersen, both of the Yale University School of Medicine. Coauthors of the study be from Yale and Harvard Medical School.



The review be support by the Medical Research Council, University of Cape Town, University of the Western Cape and University of Stellenbosch, South Africa, and the Ministry of Public Health, Cameroon.



Wiysonge CS, et al. Beta-blockers for hypertension (Review). Cochrane Database of Systematic Reviews 2007, Issue 1.



The Cochrane Collaboration be an multinational nonprofit, self-directed alliance that make and disseminate literal reviews of animation prudence arbitration and gladden the rummage around for corroboration in the rage of clinical trial and other studies of intervention. Visit for more communication.



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