Sunday, September 30, 2007

More weekend stroke patients die - Heart Health




Weekend stroke patients have higher death risk

14 percent increase may be tied to lack of expertise, resources, experts say

DALLAS - If you have a stroke, try to have it between Monday and Friday.

A Canadian study released on Thursday found that patients hospitalized for the most common kind of stroke on weekends had a higher death rate than those admitted on weekdays.

The “weekend effect” has been identified before in other conditions such as cancer and pulmonary embolism.

But this is the first major study to look at it in relation to ischemic stroke, which is caused by a clot that blocks blood flow in an artery in or leading to the brain.

“If the ‘weekend effect’ occurs in a socialized health care system (like Canada’s), it is likely that the effect may be larger in other settings,” said Dr. Gustavo Saposnik, director of the Stroke Research Unit Division of Neurology at the University of Toronto and lead author of the study.

The study, published in Stroke: Journal of the American Heart Association, looked at all ischemic stroke hospital admissions in Canada from April 2003 to March 2004.

It found that about a quarter of the 26,676 patients admitted to 606 hospitals over that time period were brought in on Saturdays and Sundays.

“After adjusting for age, gender and other medical complications, researchers found that patients admitted on the weekend had a 14 percent higher risk of dying within seven days of admission compared to patients admitted during the week,” the American Heart Association said in a statement.

The “weekend effect” was even greater when patients went to a rural hospital instead of an urban one, and when the doctor in charge was a general practitioner instead of a specialist, it said.

Researchers said the higher death risk might be linked to a relative lack of resources or expertise in hospitals during weekends. But they did not elaborate and said more study was needed.

Click for related contentProven methods to cut your heart attack riskSouped-up CT scan speeds up diagnosis

No one with stroke-like symptoms should hesitate to seek medical treatment on weekends, they added.

“Although the differences in weekend admission found in this study may be real, the potential benefits of obtaining early treatment would well outweigh the risk of waiting,” said Dr. Larry Goldstein, chair of the Stroke Council of the American Heart Association.

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Copyright 2007 Reuters Limited. All rights reserved. Republication or redistribution of Reuters content is expressly prohibited without the prior written consent of Reuters.


Saturday, September 29, 2007

Siegfried & Roy to tell all - Gossip: The Scoop




Siegfried & Roy ready
to let cat out of the bag

Plus: Ashlee Simpson a new
acid-reflux spokesperson?

NBC / AP file
Is America ready for "Siegfried & Roy: The Book"?

By By Jeannette Walls

Siegfried and Roy are ready to tell all.

Siegfried Fischbacher and Roy Horn, the hugely popular big cat tamers who were sidelined when Horn was mauled by a tiger last year, are secretly shopping around their joint memoir.

“They’re meeting with top publishers in the coming weeks,” says one insider. “It’s all very hush-hush, but apparently, they’re going to tell everything about their private and professional lives. We’re very excited about it.”

The source says the bidding will probably be in the seven-figure range.

Spokesmen for Siegfried and Roy didn’t return calls.

An ad for Ashlee?
Frank Micelotta / Getty ImagesAt least some people are pretty pleased with Ashlee Simpson’s lip synching debacle: the makers of medication for acid-reflux disease.

The teen crooner, explaining why she didn’t sing live on Saturday Night Live, said on the Today Show that her voice was hoarse because she had been suffering from “severe acid reflux.” And that makes marketers of acid reflux medications such as Nexium and Prevacid quite happy.

“Somebody of her high profile helps raise the profile of the disease,” David Albaugh of AstraZeneca �" makers of Nexium, the widely advertised “purple pill” �" told The Scoop. “Obviously, it’s good to have improved and increased awareness of acid reflux.”

“We believe that celebrities who talk about their experience with certain health conditions, such as acid reflux in this case, can help educate people on important health issues, as well as motivate people to talk to their doctors and get properly diagnosed and treated,” a spokeswoman for TAP, the company that makes Prevacid, e-mailed The Scoop in a statement. “We wish Ashlee Simpson the very best on her road to relief from acid reflux.”

RELATED STORIESAshlee Simpson busted for ‘SNL’ lip-synchingWalls: Simpson paying lip service to realitySimpson goes live at Radio Music Awards

Both companies, however, said that they have no plans at this time to ask Simpson to become their acid-reflux celebrity spokeswoman.

Notes from all over
Kevin Winter / Getty ImagesTom Cruise has a not quite impossible mission: he wants to climb Mount Everest. “That’s been a dream of mine,” the actor said at the American Film Institute, reports Zap2it.com. “I’m not a great climber, but I enjoy it.” Cruise also said he’d love to do a musical, and admits that he still sometimes sings and boogies in his underwear, like he did in “Risky Business,” saying that he calls it his “dance of freedom.”   . . . Hugh Grant joked about Julia Roberts’ “very big mouth” to Oprah Winfrey. “Literally, physically, she has a very big mouth,” Grant said of his “Notting Hill” co-star. “When I was kissing her I was aware of a faint echo.” When Winfrey defended Roberts as “one of the nicest people I ever met,” Grant deadpanned, “I wouldn’t go that far.”  . . .  Madonna used the F-word at her rabbi’s book party. The spiritual girl, speaking at the London launch for Rabbi Michael Berg’s “Becoming Like God,” at one point snapped at the crowd, “Turn those f----- mobile phones off.”

document.write("");Jeannette Walls Delivers the Scoopdocument.write(''); Mondays through Thursdays on

� 2006


Friday, September 28, 2007

Heartburn drugs linked to hip-fracture risk - Aging




Heartburn drugs tied to hip-fracture risk

Nexium, Prilosec may make it harder for body to absorb calcium, study says

CHICAGO - Taking such popular heartburn drugs as Nexium, Prevacid or Prilosec for a year or more can raise the risk of a broken hip markedly in people over 50, a large study in Britain found.

The study raises questions about the safety of some of the most widely used and heavily promoted prescription drugs on the market, taken by millions of people.

The researchers speculated that when the drugs reduce acid in the stomach, they also make it more difficult for the body to absorb bone-building calcium. That can lead to weaker bones and fractures.

Hip fractures in the elderly often lead to life-threatening complications. As a result, doctors should make sure patients have good reason to stay on heartburn drugs long term, said study co-author Dr. Yu-Xiao Yang of the University of Pennsylvania School of Medicine.

The general perception is they are relatively harmless, Yang said. They often are used without a clear or justified indication for the cure.

Some people find relief from heartburn with over-the-counter antacids such as Tums, Rolaids and Maalox. For others, these medicines do not work well. Moreover, heartburn can be more than a source of discomfort. People with chronic heartburn can develop painful ulcers in the esophagus, and in rare cases, some can end up with damage that can lead to esophageal cancer.

Dr. Sandra Dial of McGill University in Montreal, who was not involved in the study but has done similar research, said patients should discuss the risks and benefits with their doctors and taper off their use of these medicines if they can.

Nexium, Prevacid and Prilosec are members of a class of drugs known as proton pump inhibitors. The study found a similar but smaller risk of hip fractures for another class of acid-fighting drugs called H2 blockers. Those drugs include Tagamet and Pepcid.

The study, published in Wednesday??�s Journal of the American Medical Association, looked at medical records of more than 145,000 patients in England, where a large electronic database of records is available for research. The average age of the patients was 77.

The patients who used proton pump inhibitors for more than a year had a 44 percent higher risk of hip fracture than nonusers. The longer the patients took the drugs, the higher their risk.

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The biggest risk was seen in people who took high doses of the drugs for more than a year. That group had a 2?? times greater risk of hip fractures than nonusers.

Yang said that for every 1,262 elderly patients treated with the drugs for more than a year, there would be one additional hip fracture a year attributable to the drugs. For every 336 elderly patients treated for more than a year with high doses, there would be one extra hip fracture a year attributable to the drugs.

Dr. Doug Levine of AstraZeneca PLC, which makes Nexium and Prilosec, said the study does not prove that proton pump inhibitors cause hip fractures. It merely suggests a potential association, he said, adding that doctors need to monitor their patients for proper dosage and watch how long they take the drugs.

Dr. Alan Buchman of Northwestern University, who was not involved in the research, said the study should not change medical practice, since doctors already should be monitoring the bone density of elderly people taking the drugs and recommending calcium-rich diets to all patients.

Most people are not taking enough calcium to start with, he said. He also wondered if a similar result would have been found in a sunny climate, because vitamin D from sunshine helps with calcium absorption.

Also, Buchman said it not known whether the acid-fighting drugs prevent esophageal cancer. He said the risk of esophageal cancer has been exaggerated in the marketing of these drugs.

I think the risk has been overplayed and scared the community, Buchman said.

Heartburn medicines are heavily are advertised in Ask your doctor about ... commercials in this country, particularly during the evening news.

Nexium is the second-biggest-selling drug in the world, behind the cholesterol medicine Lipitor, with global sales totaling $4.6 billion last year, according to IMS Health, which tracks drug sales.

Yang and his co-authors disclosed in the paper that they have worked as consultants and received speaking fees from companies making acid-fighting drugs. The study was funded by the National Institutes of Health and the American Gastroenterological Association/GlaxoSmithKline Glaxo Institute for Digestive Health.

Men in the study had a higher drug-associated risk of hip fracture than women, possibly because women may be more aware of osteoporosis and may get more calcium in their diets, Yang said. He plans more research on whether calcium-rich diets or calcium supplements can prevent the problem.

? 2006 . .


Thursday, September 27, 2007

Got heartburn? Check your waistline - Nutrition Notes




Got heartburn? Excess weight may be to blame

Sufferers can feel better by altering diet, losing a little in the middle
Karen Collins, R.D.Special to

Karen Collins, R.D.

Are you suffering with serious heartburn? If so, your weight might have something to do with how you've been feeling �" and how you can feel better.

Gastroesophageal reflux disease, or GERD, is a common digestive disorder that can affect people of all ages. As recent studies continue to confirm the longstanding link between excess weight and GERD, soaring obesity rates are likely to lead to an increasing number of Americans who are affected by this disease.

The severe, frequent heartburn of GERD occurs when the muscle that acts as a valve between the esophagus and stomach doesn’t work properly, allowing stomach acids to back up into the esophagus, which can damage tissue.

One 2006 analysis of 20 studies, including more than 18,000 patients, showed that in the United States being overweight increased odds of developing GERD by more than 50 percent. Being obese more than doubled the odds.

Among more than 10,000 women analyzed in the Nurses’ Health Study, weight gain of more than about 10 to 20 pounds was linked with almost tripling the development of frequent heartburn symptoms.

The link between being overweight and risk of GERD is not new, but research is beginning to explain why it occurs. One recent study measured pressure within the stomach and found that each increase in body mass index (a measure of weight status) that corresponded to about a 10- to 20-pound weight jump was linked to a 10 percent increase in stomach pressure.

Test yourself Is it heartburn or something else?Researchers suggest that excess body fat, particularly around the abdomen, increases pressure in the abdomen, which in turn increases pressure in the stomach. The pressure to the stomach pushes the sphincter muscle between the stomach and esophagus to open. Overeating might also increase that pressure, and so can pregnancy.

Frequent heartburn can be serious
A report in the Journal of the American Dietetic Association on nutrition’s involvement in indigestion and heartburn noted that certain spices and acidic food and drink may cause pain in an esophagus already raw from stomach acid reflux. But these foods may take the blame for episodes that really are due to excessive portions.

Studies have also suggested that fatty foods may increase the tendency for reflux, yet research on fatty foods is unclear. In one small Italian study, for example, the total calories of meals increased the tendency for reflux over the next six hours, while raising fat content didn’t increase reflux if total calories remained the same.

With all the jokes about heartburn, it’s easy to regard it as just an uncomfortable inconvenience. Scientists say, however, that although occasional heartburn is not a worry, frequent heartburn can lead to serious complications if left untreated.

GERD is an established risk factor for esophageal adenocarcinoma, a type of esophageal cancer that has increased approximately 600 percent since 1971. If both obesity and GERD are present, the risk of this kind of cancer increases even more than seen with GERD alone.

Click for related contentTest your heartburn IQCalculate your BMICalories, not carbs, count for most dietersWhy raiding the fridge at night is a bad idea

There are a wide range of medications available to treat heartburn, some of which can be used together. If heartburn occurs several times a week, see your doctor. If the cause of heartburn is unhealthy eating habits or excess weight, it is probably hurting your health in other ways too.

Instead of trying to make unhealthy eating tolerable, it may be time to develop better eating habits and shape up to a healthy weight to reduce GERD and risk of esophageal cancer.

� 2007


Wednesday, September 26, 2007

Rosie O’Donnell won’t return to ‘The View’ - Television




Rosie O’Donnell won’t return to ‘The View’

Announcement comes two days after heated on-air fight with co-host
Yolanda Perez / AP
Elisabeth Hasselbeck, left, and Rosie O'Donnell sparred frequently on "The View," though they profess to be good friends off camera.

video•Rosie quits 'The View' early
May 25: With news that Rosie O'Donnell will not returning to 'The View,' Donald Trump comments on his feud with O'Donnell.


Rosie O’Donnell has fought her last fight at “The View.”

ABC said Friday she asked for, and received, an early exit from her contract at the daytime chatfest following her angry confrontation with co-host Elisabeth Hasselbeck on Wednesday. She was due to leave in mid-June.

It ended a colorful eight-month tenure for O’Donnell that lifted the show’s ratings but no doubt caused heartburn for show creator Barbara Walters. O’Donnell feuded with Donald Trump and frequently had snippy exchanges with the more conservative Hasselbeck.

O’Donnell said last month she would be leaving because she could not agree to a new contract with ABC executives.

“Rosie contributed to one of our most exciting and successful years at ‘The View,”’ Walters said. “I am most appreciative. Our close and affectionate relationship will not change.”

In a statement, O’Donnell said that “it’s been an amazing year and I love all three women.”

No one was feeling the love on Wednesday, when the argument with Hasselbeck began over O’Donnell’s statement last week about the war: “655,000 Iraqi civilians have died. Who are the terrorists?”

Talk show critics accused O’Donnell of calling U.S. troops terrorists. She called Hasselbeck “cowardly” for not saying anything in response to the critics.

“Do not call me a coward, because No. 1, I sit here every single day, open my heart and tell people what I believe,” Hasselbeck retorted, and their riveting exchange continued despite failed attempts by their co-hosts to cut to a commercial.

According to a New York Post report, O’Donnell’s chief writer, Janette Barber, was allegedly led out of the building on Wednesday after she was caught drawing mustaches on photographs of Hasselbeck in “The View” studios. ABC executives didn’t return repeated calls for questions on the incident Friday.

On Thursday O’Donnell had asked for a day off to celebrate her partner’s birthday. “The View” aired a taped show on Friday.

Related contentRosie’s ‘View’ won’t be the same without her Vote: Will you miss Rosie on ‘The View’?Political discussion turns personal on ‘View’Walters denies fight was ratings stunt  What do you think about her departure?

Slide show•Rosie through the years
From the ‘80s through ‘The View,’ a look at the feisty TV host’s careerOn her Web site, O’Donnell posted a scrapbooklike video on Friday with pictures and news clippings of her tenure at “The View.” Cyndi Lauper’s “Sisters of Avalon” played in the background.

A day earlier, she posted messages on her Web site indicating she might not be back.

“When painting there is a point u must step away from the canvas as the work is done,” she wrote. “Any more would take away.”

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� 2007 . .


Monday, September 24, 2007

WP: Bug mutates into medical mystery - washingtonpost.com Highlights




Bug mutates into medical mystery

Antibiotics, heartburn drugs suspected
By By Rob Stein

WASHINGTON - First came stomach cramps, which left Christina Shultz doubled over and weeping in pain. Then came nausea and fatigue -- so overwhelming she couldn't get out of bed for days. Just when she thought things couldn't get worse, the nastiest diarrhea of her life hit -- repeatedly forcing her into the hospital.

Doctors finally discovered that the 35-year-old Hilliard, Ohio, woman had an inagsdhfgdfinal bug that used to be found almost exclusively among older, sicker patients in hospitals and was usually easily cured with a dose of antibiotics. But after months of treatment, Shultz is still incapacitated.

"It's been a nightmare," said Shultz, a mother of two young children. "I just want my life back."

Shultz is one of a growing number of young, otherwise healthy Americans who are being stricken by the bacterial infection known as Clostridium difficile -- or C. diff -- which appears to be spreading rapidly around the country and causing unusually severe, sometimes fatal illness.

That is raising alarm among health officials, who are concerned that many cases may be misdiagnosed and are puzzled as to what is causing the microbe to become so much more common and dangerous.

"It's a new phenomenon. It's just emerging," said L. Clifford McDonald of the federal Centers for Disease Control and Prevention in Atlanta. "We're very concerned. We know it's happening, but we're really not sure why it's happening or where this is going."

Antibiotics to blame?
It may, however, be the laagsdhfgdf example of a common, relatively benign bug that has mutated because of the overuse of antibiotics.

"This may well be another consequence of our use of antibiotics," said John G. Bartlett, an infectious-disease expert at Johns Hopkins University in Baltimore. "It's another example of an organism that all of a sudden has gotten a lot meaner and nastier."

•More health newsIn addition, new evidence released last week suggests that the enormous popularity of powerful new heartburn drugs may also be playing a role.

The antibiotics Flagyl (metronidazole) and vancomycin still cure many patients, but others develop stubborn infections like Shultz's that take over their lives. Some resort to having their colon removed to end the debilitating diarrhea. A small but disturbingly high number have died, including an otherwise healthy pregnant woman who succumbed earlier this year in Pennsylvania after miscarrying twins.

The infection usually hits people who are taking antibiotics for other reasons, but a handful of cases have been reported among people who were taking nothing, another unexpected and troubling turn in the germ's behavior.

The infection has long been common in hospital patients taking antibiotics. As the drugs kill off other bacteria in the digestive system, the C. diff microbe can proliferate. It spreads easily through contact with contaminated people, clothing or surfaces.

Infections double
There are no national statistics, but the number of infections in hospitals appears to have doubled from 2000 to 2003 and there may be as many as 500,000 cases each year, McDonald said. Other estimates put the number in the millions.

The emerging problem first gained attention when unusually large and serious outbreaks began turning up in other countries. In Canada, for example, Quebec health officials reported last year that perhaps 200 patients died in an outbreak involving at least 10 hospitals. Similar outbreaks were reported in England and the Netherlands.

After the CDC began receiving reports of severe cases among hospital patients in the United States -- and in people who had never, or just briefly, been hospitalized -- it launched an investigation.

In the Dec. 8 issue of the New England Journal of Medicine, the CDC reported that an analysis of 187 C. diff samples found that the unusually dangerous strain that caused the Quebec cases was also involved in outbreaks at eight health care facilities in Georgia, Illinois, Maine, New Jersey, Oregon and Pennsylvania.

"This strain has somehow been able to get into hospitals widely distributed across the United States," said Dale N. Gerding of Loyola University in Chicago, who helped conduct the analysis. "We're not sure how."

But scientists do have a few clues. The dangerous strain has mutated to become resistant to a class of frequently used antibiotics known as fluoroquinolones. That means anyone taking those antibiotics for other reasons would be particularly prone to contract C. diff .

"Because this strain is resistant, it can take advantage of that situation and establish itself in the gut," Gerding said.

Experts said the resistant germ's proliferation offers the laagsdhfgdf reason why people should use antibiotics only when necessary, to reduce both their risk for C. diff and the chances that other microbes will mutate into more dangerous forms.

"That's one theory for what's happening here," said J. Thomas Lamont of Harvard Medical School. "If we reduce the number and amount of antibiotics given for trivial infections like colds and stuffy noses, we'd all be a lot better off."

Overuse of antibiotics can make germs more dangerous by killing off susceptible strains, leaving behind those that by chance have mutated to become less vulnerable to the drugs. The resistant strains then become dominant.

High toxin levels
In addition to being resistant, the dangerous C. diff strain also produces far higher levels of two toxins than do other strains, as well as a third, previously unknown toxin. That would explain why it makes people so much sicker and is more likely to kill. In Quebec, C. diff killed 6.9 percent of patients -- which is much higher than the disease's usual mortality rate -- and was a factor in more than 400 deaths.

Adding to the alarm is evidence that the infection is occurring outside of hospitals. When the CDC began looking for such cases earlier this year, investigators quickly identified 33 cases in New Hampshire, New Jersey, Ohio and Pennsylvania, including 23 people who had never been in the hospital and 10 women who had been hospitalized only briefly to deliver a baby, the agency reported this month. Eight of the patients had never taken antibiotics.

"This is the first time we've started to see this not only in people who have never been in the hospital but also in those who are otherwise perfectly healthy and have not even taken antibiotics," McDonald said.

"It's probably going on everywhere," he said.

It remains unclear whether the cases occurring outside the hospital are being caused by the same dangerous strain.

"We don't really know what's going on here," McDonald said. "We know it's changing in some ways; we know it's changing the kinds of patients it's attacking, and we know it's causing more severe disease. But we don't know exactly why."

Canadian researchers, however, have found one possible culprit: popular new heartburn drugs. Patients taking proton pump inhibitors, such as Prilosec and Prevacid, are almost three times as likely to be diagnosed with C-diff , the McGill University researchers reported in the Dec. 21 issue of the Journal of the American Medical Association. And those taking another type called H2-receptor antagonists, such as Pepcid and Zantac, are twice as likely. By suppressing stomach acid, the drugs may inadvertently help the bug, the researchers said.

Whatever the cause, the infection often resists standard treatment. That is what happened to Shultz, who had been taking antibiotics to help clear up her acne when C. diff hit in June. Because the bacterium can hibernate in protective spores, patients can be prone to recurrences. It can take multiple rounds of antibiotics -- or sometimes infusions of antibodies or ingesting competing organisms such as yeast or the bacteria found in yogurt -- to finally cure them.

"I'm trying to stay positive," Shultz said. "People tell me it does go away and I will get rid of it someday. I'm looking forward to getting my life back, but I'm not convinced I'll ever be normal again."

� 2007 The Washington Post Company


Sunday, September 23, 2007

Water good, coffee bad? Ain’t necessarily so - Health




Water good, coffee bad? Ain’t necessarily so

These and other recent medical maxims have become generally accepted as the truth. “Today” contributor Dr. Judith Reichman dissects myth from fact
FREE VIDEOFeb. 23: In this Woman's Health segment, Dr. Judith Reichman examines the health facts surrounding water and coffee as well as other medical maxims.

Today show

Today show
By By Dr. Judith Reichman"Today" contributorTODAY

We’ve heard the same prescriptions for good health repeated for years by our mothers, friends, in magazine articles and, oh yes, by our doctors.  Are they true, and are they supported by current research?  On “Today’s Woman,” “Today” show medical contributor Dr. Judith Reichman tells us that in some instances this “it’s good for you” advice ain’t necessarily so. 

Water, water everywhere! Should I drink it all?
There’s a prevailing opinion that there’s no such thing as too much water.  Does the advice “drink eight glasses a day” really hold water?  Many women believe that the more they drink, especially when it comes in designer bottles, the less they’ll eat, the more they’ll “flush” toxins from their bodies, and the moister and dewier their skin will be.  Countless magazine articles have recommended eight glasses a day (two quarts) as the gold standard of liquid health.  None of these suppositions bear medical scrutiny.  A diligent review, published in the American Journal of Physiology, could neither locate the origins of this edict, nor any evidence to support it.  The moisture in your skin will suffer only if you meet the medical standards for dehydration.  There’s no need to monitor the color of your urine or count your empty water bottles.  We have a marvelous built-in hydration control.  It’s called thirst, which works through multiple hormones and sensors in our vascular system.  Also, much of what we consume contains liquid, even though it’s not water, and despite what you’ve heard, coffee, caffeinated soft drinks and other fluids do count.  Finally, there are good reasons not to overdo fluids.  Many women complain of incontinence problems simply because their overfilled bladder contracts before they reach the toilet.  Just like most vitamins, a deficiency of water is bad, but excess is unhelpful and can even be dangerous.  If you take in fluid faster than your kidneys can process it, you could even end up with “water intoxication,” causing confusion, coma and even death.

What about other beverages?  Should we decaffeinate?
There’s no question that caffeine is a powerful psychoactive drug.  We use it as a mental stimulant (and today the act of drinking coffee in coffee shops has become a social stimulant for conversation, business meetings, and logging onto the Web).  Caffeine prevents sleepiness and sharpens thinking by blocking the action of certain neurotransmitters and lift moods by affecting dopamine.  It “revs you up” by promoting release of adrenaline, starting at doses lower than fifty milligrams, which is about the amount in a serving of black tea or cola.  It has been shown to improve muscle coordination and strength if consumed just prior to exercise or an athletic event.  It also increases energy expenditure, and to a very small extent helps us burn calories.  Because it helps relax the airways of the lungs, caffeine is associated with fewer asthma attacks in asthmatics.  And here’s an effect we’ve all noticed: it can act as a laxative.  In fact, many women rely on their morning coffee to keep them on schedule from both a gastroinagsdhfgdfinal and daily activity perspective.  Two to three cups a day may lower the incidence of Parkinson’s disease (according to Nurses’ Health Study data) and seems to decrease gallstone formation, at least in men.  However �" and there’s always a however �" there can be some negative effects, although some of which we’re warned about may be exaggerated.  The following have been associated with caffeine and may give us pause in taking that second or third cup of coffee:

Miscarriage
There may be as much as a 30 percent increase in early miscarriage of normal pregnancies for women who drink one to two cups of coffee a day.  One study has shown this goes up to 40 percent with four cups.  There’s also concern about caffeine consumption while trying to conceive.  Some studies have shown infertility rates double for women who drink more than two and a half cups of coffee a day.Cancer, coffee and smoking
No cancer correlation to caffeine has been found, except that women who smoke often do so at the same time that they drink their coffee.  There is no increase in breast cancer from caffeine, although some women find breast tenderness is worsened with increased caffeine consumption.  Osteoporosis
There is no conclusive link between caffeine and osteoporosis, but if caffeinated beverages (without milk) preclude milk or calcium-containing fluid consumption, the lack of calcium intake will correlate with osteoporosis risk.Hypertension
Caffeine can raise blood pressure for a few minutes, and in some cases hours.  However coffee consumption does not seem to cause ongoing hypertensive disorder.  If you already have hypertension, however, a cup of coffee may temporarily raise your blood pressure and this could ultimately increase your more immediate risk of stroke.Heart disease
Caffeine can cause palpitations, irregular or fast heartbeat, and if you have an existing abnormal heart rate or heart disease, this could be a problem.  One study found an increased risk of cardiac arrest in nonsmokers who consumed six or more cups of coffee a day.  But in general we can’t blame heart disease or heart attacks on reasonable caffeine consumption.Headaches
Caffeine can increase the effectiveness of headache medications (and many of the over-the-counter headache medications in fact combine caffeine with either aspirin or a Tylenol-like component).  But these combined products can actually cause rebound headaches.  To avoid this “take a pill feel better, then worse” cycle, over-the-counter medications with caffeine shouldn’t be used for more than two days at a time.PMS
Caffeine acts as a diuretic and should decrease discomfort and bloat.  But it can also cause a fall in blood sugar, which increases symptoms of PMS.  There can be a three-fold increase in PMS if we drink more than three to four cups of coffee a day.Bladder conditions
Caffeine speeds the kidneys’ processing of fluid, so we have to go more frequently.  It can also irritate the bladder, leading to certain forms of incontinence.  Caffeine and sleep
Caffeine stimulates the brain and also affects levels of melatonin, which promotes sleep.  It takes four to seven hours to metabolize caffeine.  The older we are, the longer it takes.  And if you are on birth control pills or estrogen, the half life of caffeine may be doubled.  So an afternoon cup of coffee can cause late night insomnia.Caffeine and anxiety
High doses increase the level of brain chemicals associated with anxiety.  Caffeine and heartburn
Even decaffeinated coffee can increase stomach acid production and affect the closing of the valve between the stomach and esophagus, leading to reflux and heartburn.  If you do have this problem, you not only need to decaffeinate, but you need to de-decaffeinate, i.e. no types of coffee at all.

The bottom line
In summary, caffeine does make us feel better, more alert; we sometimes exercise better, even think better.  But we should not be consuming it, especially more than one to two cups per day, if we have:

Irregular heartbeats or palpitationsSevere PMSSleep problemsBladder problemsAnxiety and/or panic attacks

If it’s Tuesday, it must be Belgian chocolate! What, if any, is the harm?
There is, of course, another product that we love that also contains some caffeine: chocolate.  We’ve been told that it’s fattening and not good for us.  “It will rot your teeth, cause acne, make you fat.”  Are these warnings true?  And what about the recent proclamations that chocolate is, to some extent, a health food?

First, the caffeine in chocolate is not very strong.  One chocolate bar contains less than a cup of coffee. Chocolate also contains a group of very healthy ingredients called flavinoids, which are antioxidants and are also contained in fruits, nuts and vegetables (and red wine).  These flavinoids, which are present in the cocoa bean, can reduce the blood’s ability to clot (like aspirin) and may also help to lower blood pressure. Part of the fat content in chocolate comes from steric acid, which works on the body like a healthy monounsaturated fat.  There is even some evidence this may help protect against cavities.  But remember, a cup of chocolate is very dense in calories, containing up to a thousand calories or more, whereas a cup of broccoli contains less than forty.  Moreover, white chocolate contains no flavinoids. Dark chocolate, which is considered the healthiest, contains two to four times the amount of flavinoids that milk chocolate has.  If you want to have a couple of pieces of dark chocolate a day, consider the calories in your total count, but in the end this may not be such an anti-health treat.

We’ve been told women should take iron supplements. Is that true?
To start, it is very important to know that iron supplements are the most common cause of poisoning deaths among children, and overload is dangerous at any age.  If you’re not anemic, doses over forty-five milligrams can cause constipation, vomiting, nausea or diarrhea.  While we have our periods and lose blood and deplete our iron stores, taking a multi-vitamin with a small amount of iron is acceptable. But as we get older and stop having periods this is not necessarily so.  One out of two hundred and fifty people of Northern European descent (and also persons of other ethnic backgrounds) have a genetic disorder called hemochromatosis.  In this condition, iron absorption is so efficient that there is build up of excess iron in the body’s organs, which can cause serious liver, heart, thyroid and joint problems, as well as liver cancer. As women menstruate for thirty or forty years this problem may not show up until after menopause.  Iron may also aid the formation of free radicals, those unstable agent disease-promoting molecules.  In fact, one theory of why younger women have less heart disease than men is that prior to menopause women’s mild iron deficiency acts as a cardiac shield against free radical damage. 

Finally, in a recent report of the Nurses’ Health Study, in which they followed thirty-two thousand women for more than ten years, they found that those women with higher iron stores were found to be at increased risk for development of type 2 diabetes.  Too much iron, as in too much of any supplement, can be harmful.  So once you’re menopausal, do not take a multivitamin with iron unless told to do so by your doctor after appropriate blood agsdhfgdfing.

The Pap smear �" does it really need to be done every year?
After age 30 we can decrease the frequency of our Pap smears to every two to three years if our past routine Pap has been normal, we are in a monogamous relationship, don’t smoke, don’t take steroids, and are not DES-exposed ( meaning your mother took DES when she was pregnant with you).  Nearly all cervical pre-cancer and cancer is due to the sexually transmitted human papilloma virus (HPV), which, although readily transmitted, is cleared by most women after a few years.  If this virus is not cleared, it will take three years or more to cause mutations in the cervical cells leading to pre-cancer and cancer. Some physicians are adding a special agsdhfgdf for HPV and if this and the Pap smear are negative, feel very assured that a three year wait (and not the usual yearly Pap) is safe and warranted.

Are carbohydrates really as bad as Dr. Atkins said?
Once again, not necessarily. A recent review published in the Journal of the A.M.E.found that there is not enough evidence to make health or diet recommendations for or against low-carb diets. Another article, published in the New England Journal of Medicine, showed that low-carb diets (with high fat and high protein) are more effective for weight loss in obese individuals when compared with low fat diets (fewer than twenty-five percent of calories from fat), but only during the initial three and six months. By the end of the year, those who stayed on the low-carb diet (and many couldn't) did not lose more weight. And those who succeeded in losing weight in the first place did so because they ate fewer calories. It’s the total calories that count! The American Heart Association has not recommended a low-carb diet, stating that there is no evidence that the diet is effective long term in improving health. Against a strict restriction of carbs for weight control is a 12-year Harvard study of 74,000 women which showed that those who consumed more fruits and vegetables were 26 percent less likely to become obese than women who ate fewer fruits and vegetables over the same period of time.

Part of the puzzle is that not all carbs are created equal. Refined carbohydrates, such as white rice, white bread and of course sugar �" and potatoes �" cause rapid spikes in blood sugar and hence raise insulin levels. Insulin can then cause fat to accumulate in the body, especially around the waist, and wrong fats (triglycerides) to accumulate in the blood stream, contributing to plaque and heart disease.  Complex carbs (think whole grains that are not denuded during so-called "refining") are digested slowly and don't cause a sudden blood sugar surge. They also contain important fiber, vitamins and phyto (plant) chemicals. When you stop consuming these "made for us by nature" carbohydrates and substitute protein and fat, you can eventually cause considerable harm. In the short term you may feel tired, dizzy, nauseated and dehydrated. With time, lack of carb balance can lead to deficiencies in vitamins and minerals. A lack of fiber often results in constipation and this increases your risk for development of diverticulosis (weakened pouches that develop in the bowel wall) and possibly even colon cancer. A diet with the wrong fats, i.e. saturated fats found in meat and whole milk and the trans fats in many processed foods and margarines, will contribute to heart disease. Too much protein can lower absorption of calcium, leading to osteoporosis, and can stress your kidneys.

We don't need a general carb-out.  If you want to keep your weight down and stay healthy, do the known, right stuff: eat plenty of vegetables and fruits, and substitute whole grains, some nuts, and healthy oils for sugar, white starch and saturated fats.  And of course, don't smoke, and make sure you exercise!

Dr. Judith Reichman has practiced obstetrics and gynecology for more than 20 years. She is a regular “Today” show contributor.

� 2007